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Endotelialiserade Mikrofluidik för att studera Mikrovaskulära Interaktioner i hematologiska sjukdomar
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1Department of Pediatrics,Emory University School of Medicine, 2Wallace H. Coulter Department of Biomedical Engineering,Georgia Institute of Technology and Emory University, 3Aflac Cancer Center and Blood Disorders Service of Children’s Healthcare of Atlanta , 4Winship Cancer Institute of Emory University
Chapters
- 00:05Title
- 01:11Fabrication of the Endothelial Microdevice
- 03:46Polydimethylsiloxane (PDMS) Preparation
- 06:25Seeding the Microfluidic Device with Endothelial Cells
- 08:49Endothelialized Microfluidics Reveal Abnormal Microvascular Interactions after Infusion with Blood from Patients with Hematologic Disease
- 10:35Conclusion
En metod att odla en endotelcell monoskikt under hela inre 3D ytan av en mikrofluidanordning med mikrovaskulär storlek kanaler (<30 pm) beskrivs. Detta<em> In vitro</em> Mikrovaskulaturen modell möjliggör studiet av biofysikaliska interaktioner mellan blodceller, endotelceller och lösliga faktorer i hematologiska sjukdomar.
Tags
MicrofluidicsEndothelialized MicrofluidicsMicrovascular InteractionsHematologic DiseasesMicrofabrication TechniquesBiological ExperimentsBiochemical ExperimentsMicro- And NanoscalesHematologic ProcessesBlood Cell DeformabilityBlood Cell AggregationMicrovascular Blood FlowBlood Cell-endothelial Cell InteractionsCultured Endothelial CellsMicrocirculationBiophysical Pathophysiology
