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Hypoglycemia refers to an abnormally low blood glucose level, typically below 70 milligrams per deciliter.
It mainly affects individuals with type 1 diabetes who depend on insulin, but it can also develop in patients with type 2 diabetes who use insulin or insulin secretagogues.
It typically results from a mismatch between circulating insulin and the body’s glucose demands.
Common risk factors include excessive insulin dosing, missed meals, and vigorous exercise without carbohydrate compensation.
In non-diabetic individuals, fasting or exercise lowers insulin levels and triggers counter-regulatory hormones like glucagon and epinephrine.
These raise hepatic glucose output and limit peripheral glucose uptake to maintain normoglycemia.
In diabetes, especially with exogenous insulin or insulin-stimulating drugs, these defenses may be blunted.
High insulin levels prevent glucose recovery, increasing the risk of severe hypoglycemia.
Clinical manifestations of hypoglycemia may include hunger, tremor, confusion, seizures, and coma.
Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise i…
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