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JoVE Journal
Biology

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An Analytical Tool that Quantifies Cellular Morphology Changes from Three-dimensional Fluorescence Images
 

An Analytical Tool that Quantifies Cellular Morphology Changes from Three-dimensional Fluorescence Images

Article doi: 10.3791/4233
August 31st, 2012 Usage Statistics

Summary August 31st, 2012

We developed a software platform that utilizes Imaris Neuroscience, ImarisXT and MATLAB to measure the changes in morphology of an undefined shape taken from three-dimensional confocal fluorescence of single cells. This novel approach can be used to quantify changes in cell shape following receptor activation and therefore represents a possible additional tool for drug discovery.

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