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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
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Immunology and Infection
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JoVE Journal Immunology and Infection
Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

DOI:
10.3791/4276-v

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07:27 min

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December 18, 2012

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, , , , ,
1Department of Ophthalmology,Saint Louis University

Chapters

  • 00:05Title
  • 01:28Preparation of Virus
  • 03:11Mouse Infection
  • 04:19Reactivation of Mice from Latency
  • 05:13Clinical Evaluation
  • 06:03Results: Gender Differences in Mice Undergoing HSK Reactivation
  • 07:00Conclusion

Summary

Automatic Translation

Automatic Translation

Most studies of herpetic corneal disease use a primary infection model. However, primary infection with HSV-1 does not typically lead to human disease. Here we describe a recurrent model of herpetic corneal disease, which more closely mimics human disease.

Tags

Recurrent Herpetic Stromal KeratitisHSKHerpetic Eye DiseaseCornea InfectionHerpes Simplex Type I VirusClinical DiseaseRecurrent ModelAnimal ModelsRabbitsMiceImmunological FactorsGenetic ResourcesMouse ModelUV-B Light Exposure

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