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Journal / Medicine / Neo-Islet Formation in Leber der diabetischen…
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Neo-Islet Formation in Leber der diabetischen Mäuse von Helper-abhängigen Adenovirus-Vektor-vermittelten Gentransfer
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Neo-Islet Formation in Leber der diabetischen Mäuse von Helper-abhängigen Adenovirus-Vektor-vermittelten Gentransfer

Article DOI: 10.3791/4321-v • 16:59 min • October 10th, 2012
October 10th, 2012 •
1,2, 1,2,3, 1,2,3
1Department of Medicine, Baylor College of Medicine, 2Division of Diabetes, Endocrinology & Metabolism, Diabetes & Endocrinology Research Center, Baylor College of Medicine, 3Department of Molecular & Cellular Biology, Baylor College of Medicine

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Wir beschreiben hepatische neo-Inselzellen Formation in STZ (Streptozotocin)-induzierte diabetische Mäuse durch Gentransfer von Neurogenin3 (Ngn3) und Betacellulin (BTC) Verwendung von Helfer-abhängigen Adenovirus-Vektor (HDAd) und der Umkehrung von Hyperglykämie. Unsere Methode nutzt die Vorteile von Helfer-abhängigen Adenovirus-Vektoren mit ihren hocheffizienten in vivo Transduktion und der lang anhaltende Genexpression.

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Medizin Genetik Physiologie Gentherapie Neurogenin3 Betacellulin Helfer-abhängigen Adenovirus-Vektoren Diabetes Typ 1 Inselneogenese
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