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Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat
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Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat

Article DOI: 10.3791/50014-v • 07:26 min • February 16th, 2013
February 16th, 2013 •
1, 2, 1, 3, 4, 4, 1, 3
1Department of Neurosurgery, University of Florida, 2Department of Anatomical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran, 3Department of Physiology and Functional Genomics, University of Florida, 4Department of Neurology, University of Florida

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Summary
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Several animal models of cerebral ischemia have been developed to simulate the human condition of stroke. This protocol describes the endothelin-1 (ET-1) induced middle cerebral artery occlusion (MCAO) model for ischemic stroke in rats. In addition, important considerations, advantages, and shortcomings of this model are discussed.

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Endothelin-1 Middle Cerebral Artery Occlusion Ischemic Stroke Model Laser Doppler Flowmetry Guidance Rat Stroke Cerebral Ischemia ET-1 Induction Craniotomy Stereotaxic Injection Artery Constriction Control Reperfusion Rates Stroke Volume Variability Laser Doppler Flowmetry (LDF)
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