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Immunology and Infection

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JoVE Journal Immunology and Infection
Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Intralymphatic Immunotherapy and Vaccination in Mice
Journal (Immunology and Infection)
Intralymphatic Immunotherapy and Vaccination in Mice
Isolation, Processing and Analysis of Murine Gingival Cells
Journal (Immunology and Infection)
Isolation, Processing and Analysis of Murine Gingival Cells
 

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Article DOI: 10.3791/50409-v • 05:53 min • July 6th, 2013
July 6th, 2013 •
1, 1, 1, 1
1ImmunoRhumatologie Moléculaire, INSERM UMR_S 1109, Centre de Recherche d'Immunologie et d'Hématologie, Université de Strasbourg

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Summary
Automatic Translation

Human Cytomegalovirus (HCMV) infection of neonates represents an important cause of mental retardation, yet the molecular events leading to virus-induced pathogenesis are still poorly understood. To investigate the dynamics of brain infection, we adapted whole-animal in vivo imaging to perform time-course analysis of neonates infected with a luciferase-recombinant virus.

Tags

In Vivo Imaging Experimental Mouse Cytomegalovirus Infection Neonates Human Cytomegalovirus HCMV HHV-5 Immune-compromised Individuals Congenital Infection Neonatal Infection Developing Brain Neurological Damage Deafness Mental Retardation Therapeutic Options Vaccine Antiviral Therapy Central Nervous System (CNS) Molecular Events Autopsy Rhesus Macaque CMV CMV Pathogenesis Intracranial Inoculation Procedure Ethical Considerations Newborn Mice Mouse Cytomegalovirus (MCMV) Balb/c Neonates Neurons Glial Cells
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