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Tibial Nerve Transection – A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice
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Tibial Nerve Transection – A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice

Tibial Nerve Transection – A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice

DOI:
10.3791/50657-v

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10:50 min

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November 03, 2013

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,
1Keenan Research Centre of the LiKaShing Knowledge Institute,St Michaels Hospital, 2Department of Surgery,McMaster University

Chapters

  • 00:05Title
  • 01:31Surgical Procedure
  • 05:03Post Operative Care
  • 06:13Denervated Gastrocnemius and Soleus Muscle Harvest
  • 09:24Results: Muscle Atrophy in Denervated Mice
  • 10:21Conclusion

Summary

Automatic Translation

Automatic Translation

The tibial nerve transection model is a well-tolerated, validated, and reproducible model of skeletal muscle atrophy. The model surgical protocol is described and demonstrated in C57Black6 mice.  

Tags

Keywords: Tibial Nerve TransectionDenervation-induced Skeletal Muscle AtrophyRodent ModelGastrocnemius MuscleMuscle Fiber TypeC57Black6 Mouse

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