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Journal / Immunology and Infection / Myelin Oligodendrozyten Glykoprotein (MOG
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Immunology and Infection

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JoVE Journal Immunology and Infection
Myelin Oligodendrozyten Glykoprotein (MOG
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Myelin Oligodendrozyten Glykoprotein (MOG

Article DOI: 10.3791/51275-v • 08:03 min • April 15th, 2014
April 15th, 2014 •
1,2, 1, 1, 1,3
1Department of Neurology, University of Münster, 2Interdisciplinary Center for Clinical Research (IZKF), Münster, 3Institute of Physiology – Neuropathophysiology, University of Münster

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Experimentelle Autoimmun-Enzephalomyelitis (EAE) ist ein etabliertes Tiermodell für multiple Sklerose. C57BL / 6 Mäuse mit Myelin-Oligodendrozyten-Glykoprotein (MOG)-Peptid 35-55 (MOG 35-55) immunisiert, was zu einer aufsteigenden schlaffen Lähmung durch autoreaktive Immunzellen im zentralen Nervensystem verursacht. Protokolle für die Krankheitsinduktion und Überwachung diskutiert.

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Immunologie der experimentellen autoimmunen Enzephalomyelitis EAE Multiple Sklerose MS Tiermodell Autoimmunität neuroinflammation zentrales Nervensystem Pertussis
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