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JoVE Journal
Neuroscience

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Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
 

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

Article doi: 10.3791/51458
March 20th, 2014 Usage Statistics

Summary March 20th, 2014

Here we describe an adaptation of protocols used to induce homeostatic plasticity in neurons for the study of plasticity of astrocytic G protein-coupled receptors. Recently used to examine changes in astrocytic group I mGluRs in juvenile mice, the method can be applied to measure scaling of various astrocytic GPCRs, in tissue from adult mice in situ and in vivo, and to gain a better appreciation of the sensitivity of astrocytic receptors to changes in neuronal activity.

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