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Chapters
- 00:05Title
- 01:51Ad-eluting Stent Deployment in the Rat Carotid Model of Stent Angioplasty
- 05:37Bioluminescence Imaging of Arterial Gene Expression
- 09:00Systemic Administration of Luciferin
- 09:55Representative Bioluminescence Imaging Following Placement of AdLUC-eluting Stents
- 11:46Conclusion
These studies report on reversible attachment of adenoviral gene vectors to coatless metal surfaces of stents and model mesh disks. Sustained release of transduction-competent viral particles contingent upon hydrolysis of cross-linkers used for vector immobilization results in a durable site-specific transgene expression in vascular cells and in stented arteries.
