Robert J. Levy

Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania

Affiliated withThe Children's Hospital of Philadelphia, University of Pennsylvania The Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 12	2014
Publication title Cited by 17	2014
Publication title Cited by 2	2020

Other Publications

Article	Year
Gene delivery to pig coronary arteries from stents carrying antibody-tethered adenovirus. Human gene therapy\| PubMed ID: 11860711	2002
Endovascular microcoil gene delivery using immobilized anti-adenovirus antibody for vector tethering. Stroke; a journal of cerebral circulation\| PubMed ID: 11988618	2002
Thymosin beta4 regulation, expression and function in aortic valve interstitial cells. The Journal of heart valve disease\| PubMed ID: 12358412	2002
Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells. The American journal of pathology\| PubMed ID: 12466127	2002
Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells. The American journal of pathology\| PubMed ID: 12466135	2002
Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. The Annals of thoracic surgery\| PubMed ID: 12607654	2003
Calcification resistance with aluminum-ethanol treated porcine aortic valve bioprostheses in juvenile sheep. The Annals of thoracic surgery\| PubMed ID: 12683574	2003
Inhibition of cusp and aortic wall calcification in ethanol- and aluminum-treated bioprosthetic heart valves in sheep: background, mechanisms, and synergism. The Journal of heart valve disease\| PubMed ID: 12701794	2003
The incorporation of an ion channel gene mutation associated with the long QT syndrome (Q9E-hMiRP1) in a plasmid vector for site-specific arrhythmia gene therapy: in vitro and in vivo feasib... Human gene therapy\| PubMed ID: 12828861	2003
Prevention of polyurethane valve cusp calcification with covalently attached bisphosphonate diethylamino moieties. Journal of biomedical materials research. Part A\| PubMed ID: 12889009	2003
Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 14499195	2003
Delivery and expression of pDNA embedded in collagen matrices. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 14980779	2004
Ethanol inhibition of porcine bioprosthetic heart valve cusp calcification is enhanced by reduction with sodium borohydride. The Journal of heart valve disease\| PubMed ID: 15222297	2004
Modulation of eomes activity alters the size of the developing heart: implications for in utero cardiac gene therapy. Human gene therapy\| PubMed ID: 15353039	2004
Transcription factor Egr-1 in calcific aortic valve disease. The Journal of heart valve disease\| PubMed ID: 15597579	2004
Cholesterol-derivatized polyurethane: characterization and endothelial cell adhesion. Journal of biomedical materials research. Part A\| PubMed ID: 15625684	2005
Triglycidylamine crosslinking of porcine aortic valve cusps or bovine pericardium results in improved biocompatibility, biomechanics, and calcification resistance: chemical and biological me... The American journal of pathology\| PubMed ID: 15631995	2005
Prevention of calcification of bioprosthetic heart valve cusp and aortic wall with ethanol and aluminum chloride. The Annals of thoracic surgery\| PubMed ID: 15734402	2005
Calcification of tissue heart valve substitutes: progress toward understanding and prevention. The Annals of thoracic surgery\| PubMed ID: 15734452	2005
Posttranslational control of a cardiac ion channel transgene in vivo: clarithromycin-hMiRP1-Q9E interactions. Human gene therapy\| PubMed ID: 16000071	2005
Site specific gene delivery in the cardiovascular system. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 16298010	2005
Cholesterol-modified polyurethane valve cusps demonstrate blood outgrowth endothelial cell adhesion post-seeding in vitro and in vivo. The Annals of thoracic surgery\| PubMed ID: 16368333	2006
Bisphosphonate-mediated gene vector delivery from the metal surfaces of stents. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16371477	2006
Serotonin transporter mechanisms and cardiac disease. Circulation\| PubMed ID: 16391164	2006
Surface heparinization of polyurethane via bromoalkylation of hard segment nitrogens. Biomacromolecules\| PubMed ID: 16398531	2006
Prevention of oxidative degradation of polyurethane by covalent attachment of di-tert-butylphenol residues. Journal of biomedical materials research. Part A\| PubMed ID: 16736485	2006
Adenoviral gene vector tethering to nanoparticle surfaces results in receptor-independent cell entry and increased transgene expression. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16807119	2006
In-vivo dynamic deformation of the mitral valve anterior leaflet. The Annals of thoracic surgery\| PubMed ID: 16996935	2006
Mechanisms of the in vivo inhibition of calcification of bioprosthetic porcine aortic valve cusps and aortic wall with triglycidylamine/mercapto bisphosphonate. Biomaterials\| PubMed ID: 17027944	2007
[Animal study of intravascular gene therapy based on polyurethane implantable devices]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae\| PubMed ID: 17121231	2006
Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events. The Annals of thoracic surgery\| PubMed ID: 17307438	2007
Biological stability of polyurethane modified with covalent attachment of di-tert-butyl-phenol. Journal of biomedical materials research. Part A\| PubMed ID: 17370325	2007
Magnetically driven plasmid DNA delivery with biodegradable polymeric nanoparticles. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17403937	2007
In vivo biomechanical assessment of triglycidylamine crosslinked pericardium. Biomaterials\| PubMed ID: 17822757	2007
High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18182491	2008
Immobilization of plasmid DNA on an anti-DNA antibody modified coronary stent for intravascular site-specific gene therapy. The journal of gene medicine\| PubMed ID: 18213735	2008
Local delivery of gene vectors from bare-metal stents by use of a biodegradable synthetic complex inhibits in-stent restenosis in rat carotid arteries. Circulation\| PubMed ID: 18413497	2008
Site-specific analgesia with sustained release liposomes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19416926	2009
Magnetically responsive biodegradable nanoparticles enhance adenoviral gene transfer in cultured smooth muscle and endothelial cells. Molecular pharmaceutics\| PubMed ID: 19496618	2009
Biomechanical and biologic effects of meniscus stabilization using triglycidyl amine. Journal of biomedical materials research. Part A\| PubMed ID: 19557790	2010
SnapShot: calcification of bioprosthetic heart valves. Biomaterials\| PubMed ID: 19623686	2009
Fenfluramine disrupts the mitral valve interstitial cell response to serotonin. The American journal of pathology\| PubMed ID: 19679875	2009
Analytical chemistry: The matrix neutralized. Nature\| PubMed ID: 19829362	2009
Site-specific gene therapy for cardiovascular disease. Current opinion in drug discovery & development\| PubMed ID: 20205054	2010
Prevention of polyurethane oxidative degradation with phenolic antioxidants covalently attached to the hard segments: structure-function relationships. Journal of biomedical materials research. Part A\| PubMed ID: 20306526	2010
Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20404175	2010
Endothelial delivery of antioxidant enzymes loaded into non-polymeric magnetic nanoparticles. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 20483366	2010
CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-modified polyurethane. Biomaterials\| PubMed ID: 20538335	2010
Micropatterning of three-dimensional electrospun polyurethane vascular grafts. Acta biomaterialia\| PubMed ID: 20601235	2010
The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials\| PubMed ID: 21429575	2011
Aortic valve cyclic stretch causes increased remodeling activity and enhanced serotonin receptor responsiveness. The Annals of thoracic surgery\| PubMed ID: 21718840	2011
Triglycidyl amine crosslinking combined with ethanol inhibits bioprosthetic heart valve calcification. The Annals of thoracic surgery\| PubMed ID: 21871270	2011
Immobilization of gene vectors on bisphosphonate-mediated gene-eluting metal stents using antibody for localized gene delivery. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22195832	2011
Formulation and in vitro characterization of composite biodegradable magnetic nanoparticles for magnetically guided cell delivery. Pharmaceutical research\| PubMed ID: 22274555	2012
Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces. Biomaterials\| PubMed ID: 22613135	2012
Blood flow reprograms lymphatic vessels to blood vessels. The Journal of clinical investigation\| PubMed ID: 22622036	2012
Antioxidant enzymes reduce DNA damage and early activation of valvular interstitial cells in aortic valve sclerosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23241403	2013
Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23407712	2013
Anchoring of self-assembled plasmid DNA/anti-DNA antibody/cationic lipid micelles on bisphosphonate-modified stent for cardiovascular gene delivery. International journal of nanomedicine\| PubMed ID: 23687446	2013
Adenoviral vector tethering to metal surfaces via hydrolyzable cross-linkers for the modulation of vector release and transduction. Biomaterials\| PubMed ID: 23777912	2013
Intracellular signaling mechanisms associated with CD47 modified surfaces. Biomaterials\| PubMed ID: 23948164	2013
Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: implications for gene therapy of restenosis. Atherosclerosis\| PubMed ID: 23958248	2013
The susceptibility of bioprosthetic heart valve leaflets to oxidation. Biomaterials\| PubMed ID: 24360721	2014
Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation. Biomaterials\| PubMed ID: 24480537	2014
Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24591603	2014