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An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

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07:45 min

October 21, 2014

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07:45 min
October 21, 2014

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Summary

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Globoid cells are a defining pathological feature of Krabbe disease, a leukodystrophy currently lacking an effective long-term therapy. We have developed a cell culture model to study the innate biology and pathogenic potential of activated microglia and their transformation into globoid cells.

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