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Neuroscience

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An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
 

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

Article DOI: 10.3791/51903
October 21st, 2014

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Summary October 21st, 2014

Globoid cells are a defining pathological feature of Krabbe disease, a leukodystrophy currently lacking an effective long-term therapy. We have developed a cell culture model to study the innate biology and pathogenic potential of activated microglia and their transformation into globoid cells.

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