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JoVE Journal
Neuroscience

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JoVE Journal Neuroscience
Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane
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Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Article DOI: 10.3791/52187
March 16th, 2015 •
1, 1, 1, 1
1Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco

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March 16th, 2015

The described post-auricular surgical approach allows rapid and direct delivery into the mouse cochlear scala tympani while minimizing blood loss and animal mortality. This method can be used for cochlear therapy using molecular, pharmacologic and viral delivery to postnatal mice through the round window membrane.

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