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Immunology and Infection

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Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
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Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations

Article DOI: 10.3791/52351
January 10th, 2015 •
1, 1, 2
1Department of Microbiology and Immunology, Wake Forest University Health Sciences, 2R&D Department, R.J. Reynolds Tobacco Company

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January 10th, 2015

Using optimized human peripheral blood mononuclear cell (PBMC) ex vivo assays, we showed that a combustible tobacco product preparation markedly suppresses receptor-mediated intracellularly secreted cytokines and cytolytic ability of effector PBMCs. These rapid assays may be useful in product evaluation and understanding the potential long-term effects of tobacco exposure.

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