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Journal / Neuroscience / Experimental Demyelination and Remyelination of…
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Neuroscience

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JoVE Journal Neuroscience
Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
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Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Article DOI: 10.3791/52679 • 08:57 min • March 26th, 2015
March 26th, 2015 •
1, 1, 1,2
1Department of Clinical Neurosciences, Hotchkiss Brain Institute at University of Calgary, 2Department of Oncology, Hotchkiss Brain Institute at University of Calgary

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Summary
Automatic Translation

Demyelinating diseases can be modeled in animals by focal application of lysolecithin into the CNS. A single injection of lysolecithin into mouse spinal cord produces a lesion that spontaneously repairs over time. The goal is to study factors involved in de- and remyelination, and to test agents for enhancing repair.

Tags

Experimental Demyelination Remyelination Murine Spinal Cord Lysolecithin Injection Multiple Sclerosis Oligodendrocytes Myelin Axons Neurons Immune Component Therapeutics Neurological Decline Remyelination-promoting Strategies Animal Models Of Demyelination Experimental Autoimmune Encephalomyelitis Cuprizone Focal Injection Of Toxins Central Nervous System White Matter Rodents Surgical Procedure
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