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JoVE Journal
Neuroscience

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Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
 

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Article DOI: 10.3791/52679
March 26th, 2015

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Summary March 26th, 2015

Demyelinating diseases can be modeled in animals by focal application of lysolecithin into the CNS. A single injection of lysolecithin into mouse spinal cord produces a lesion that spontaneously repairs over time. The goal is to study factors involved in de- and remyelination, and to test agents for enhancing repair.

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