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An Orthotopic Mouse Model of Spontaneous Breast Cancer Metastasis
An Orthotopic Mouse Model of Spontaneous Breast Cancer Metastasis
JoVE Journal
Medicine
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JoVE Journal Medicine
An Orthotopic Mouse Model of Spontaneous Breast Cancer Metastasis

An Orthotopic Mouse Model of Spontaneous Breast Cancer Metastasis

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08:11 min
August 14, 2016

DOI: 10.3791/54040-v

,

1Department of Biochemistry and Molecular Biology, Medical College of Georgia,Augusta University, 2Georgia Cancer Center,Augusta University, 3Charlie Norwood VA Medical Center

An orthotopic breast cancer primary tumor model and surgical removal of primary tumor to extend mouse life to generate spontaneous metastasis are described. The tumor growth and progression are monitored and quantified by luciferase fluorescence imaging.

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Orthotopic Mouse ModelSpontaneous Breast Cancer Metastasis4T1 Luciferase CellsBALB/c MiceBioluminescence ImagingPrimary Tumor GrowthMetastasis Kinetics

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