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Chapters
- 00:05Title
- 00:52Isolating the Heart and Lungs
- 02:26Aortic Cannulation
- 06:07Pulmonary Vein Occlusion, Preparation of the Pulmonary Artery for Cannulation, and Left Atrial Cannulation
- 09:37Pulmonary Artery Cannulation and Working Heart Mode Experimentation
- 10:45Results: The Effects of Dopamine on the Working Heart
- 12:23Conclusion
Isolated working heart models can be used to measure the effect of loading conditions, heart rate, and medications on myocardial performance and oxygen consumption. We describe methods for preparation of a rodent left heart working model that permits study of systolic and diastolic performance and oxygen consumption under various conditions.
Tags
Keywords:
RodentWorking Heart ModelMyocardial PerformanceOxygen ConsumptionCardiovascular PhysiologyVentricular LoadingContractilityDissectionIsolationAortaLeft AtriumPulmonary VeinsSedationAnalgesiaAnticoagulationHeparinPeritoneal CavityDiaphragmThoraxPericardiumPleuraInferior Vena CavaAortaEsophagusTracheaBrachiocephalic ArteriesVeinsThymusLangendorff ApparatusAortic ValveRight Subclavian Artery
