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Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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Cancer Research
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JoVE Journal Cancer Research
Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

DOI:
10.3791/54798-v

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13:38 min

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January 18, 2017

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, , , ,
1Physiology and Biophysics, College of Medicine,University of Illinois at Chicago, 2Medicinal Chemistry and Pharmacognosy, College of Medicine,University of Illinois at Chicago, 3College of Pharmacy,University of Illinois at Chicago

Chapters

  • 00:05Title
  • 01:13Synthesis of Aspirin-fumarate Prodrug, GTCpFE
  • 06:10Inhibiting the NFκB Activity with GTCpFE in Breast Cancer Cells
  • 07:22Inhibiting Breast Cancer Stem Cells with GTCpFE In Vitro
  • 10:11Results: GTCpFE Inhibits the NFκB Pathway, Mammosphere Formation, and the CD44+CD24– Immunophenotype in Breast Cancer Cells
  • 11:49Conclusion

Summary

Automatic Translation

Automatic Translation

This procedure will demonstrate how we synthesized and characterized the anti-NFκB and anti-cancer stem cell activity of an aspirin-fumarate prodrug.

Tags

Keywords: Aspirin-fumarate ProdrugGTCpFEAnti-inflammatoryNF-κB InhibitionBreast Cancer Stem CellsSynthesisCharacterizationAnti-cancer ActivityRepurposed DrugsMultidisciplinary Approach

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