Colin Farquharson

Division of Developmental Biology, University of Edinburgh

Affiliated withUniversity of Edinburgh The University of Edinburgh

Research Area

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 50	2014
Publication title Cited by 24	2016
Publication title Cited by 16	2017

Other Publications

Article	Year
Gradual reactivation over time of vascular tissue angiotensin I to angiotensin II conversion during chronic lisinopril therapy in chronic heart failure. Journal of the American College of Cardiology\| PubMed ID: 11869839	2002
Allopurinol improves endothelial dysfunction in chronic heart failure. Circulation\| PubMed ID: 12105162	2002
Differences in metabolic parameters and gene expression related to osteochondrosis/osteoarthrosis in pigs fed 25-hydroxyvitamin D3. Veterinary research\| PubMed ID: 12199365	2002
Aldosterone induces acute endothelial dysfunction in vivo in humans: evidence for an aldosterone-induced vasculopathy. Clinical science (London, England : 1979)\| PubMed ID: 12241543	2002
Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily. Protein engineering\| PubMed ID: 14983068	2003
PHOSPHO1-A novel phosphatase specifically expressed at sites of mineralisation in bone and cartilage. Bone\| PubMed ID: 15050893	2004
Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities. The Biochemical journal\| PubMed ID: 15175005	2004
Tonic levels of angiotensin II reduce tonic levels of vascular nitric oxide even in salt-replete man. Journal of the renin-angiotensin-aldosterone system : JRAAS\| PubMed ID: 15295720	2004
Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes. International journal of molecular medicine\| PubMed ID: 15583837	2005
Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. Biochimica et biophysica acta\| PubMed ID: 16054448	2005
Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes. Journal of cellular physiology\| PubMed ID: 16155924	2006
The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization. Bone\| PubMed ID: 16837257	2006
Effect of spironolactone on C-reactive protein levels in patients with heart disease. International journal of cardiology\| PubMed ID: 16899309	2007
Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 17227223	2007
IGF-I signalling in bone growth: inhibitory actions of dexamethasone and IL-1beta. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society\| PubMed ID: 17590365	2007
Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues. Neuroendocrinology\| PubMed ID: 17895620	2007
Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1. Biochemical and biophysical research communications\| PubMed ID: 18471996	2008
Genetic selection for fast growth generates bone architecture characterised by enhanced periosteal expansion and limited consolidation of the cortices but a diminution in the early responses... Bone\| PubMed ID: 19409517	2009
Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 19874193	2010
Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick. Bone\| PubMed ID: 20053388	2010
Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 20684022	2011
PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures. Bone\| PubMed ID: 21272676	2011
The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells. PloS one\| PubMed ID: 21611184	2011
Social networking between cells of the foetal skeleton: the importance of thyroid hormones. The Journal of endocrinology\| PubMed ID: 21680616	2011
Sodium fluoride induces apoptosis and alters bcl-2 family protein expression in MC3T3-E1 osteoblastic cells. Biochemical and biophysical research communications\| PubMed ID: 21708129	2011
The skeleton: no bones about it. The Journal of endocrinology\| PubMed ID: 21784772	2011
SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 22228213	2012
Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice. PloS one\| PubMed ID: 22359666	2012
Extracellular matrix mineralization promotes E11/gp38 glycoprotein expression and drives osteocytic differentiation. PloS one\| PubMed ID: 22586496	2012
The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling. The Journal of endocrinology\| PubMed ID: 22700194	2012
Cartilage development and degeneration: a Wnt Wnt situation. Cell biochemistry and function\| PubMed ID: 22714865	2012
Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling. Pediatric nephrology (Berlin, Germany)\| PubMed ID: 22886280	2013
Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 22887744	2013
Mechanisms and clinical consequences of vascular calcification. Frontiers in endocrinology\| PubMed ID: 22888324	2012
Suppression of mammalian bone growth by membrane transport inhibitors. Journal of cellular biochemistry\| PubMed ID: 23059814	2013
A protective role for FGF-23 in local defence against disrupted arterial wall integrity? Molecular and cellular endocrinology\| PubMed ID: 23523568	2013
Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling. Journal of bone and mineral metabolism\| PubMed ID: 23925391	2014
Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting. PloS one\| PubMed ID: 24023619	2013
Upregulation of IGF2 expression during vascular calcification. Journal of molecular endocrinology\| PubMed ID: 24482492	2014
Ablation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 24825455	2014
Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1. Bioorganic & medicinal chemistry letters\| PubMed ID: 25124115	2014
Reference point indentation is not indicative of whole mouse bone measures of stress intensity fracture toughness. Bone\| PubMed ID: 25280470	2014
BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway. Journal of cellular and molecular medicine\| PubMed ID: 25297851	2014
Deficiency of the bone mineralization inhibitor NPP1 protects against obesity and diabetes. Disease models & mechanisms\| PubMed ID: 25368121	2014
An investigation of the mineral in ductile and brittle cortical mouse bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 25418329	2015
Piroxicam treatment augments bone abnormalities in interleukin-10 knockout mice. Inflammatory bowel diseases\| PubMed ID: 25569742	2015
Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1. Journal of cellular physiology\| PubMed ID: 25833299	2015
The Functional co-operativity of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 during initiation of Skeletal Mineralization. Biochemistry and biophysics reports\| PubMed ID: 26457330	2015
E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models. Journal of cellular physiology\| PubMed ID: 26639105	2016
Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 26773408	2016
Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues. International journal of molecular sciences\| PubMed ID: 28035954	2016
End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles. Journal of cellular physiology\| PubMed ID: 28369848	2017
Skeletal energy homeostasis: a paradigm of endocrine discovery. The Journal of endocrinology\| PubMed ID: 28455432	2017
Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation. Journal of cellular physiology\| PubMed ID: 28488815	2017
A distinctive patchy osteomalacia characterises Phospho1-deficient mice. Journal of anatomy\| PubMed ID: 28737011	2017
PLA2 and ENPP6 may act in concert to generate phosphocholine from the matrix vesicle membrane during skeletal mineralization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 28864658	2017
Animal models to explore the effects of glucocorticoids on skeletal growth and structure. The Journal of endocrinology\| PubMed ID: 29051192	2017
Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation. Frontiers in physiology\| PubMed ID: 29089903	2017