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JoVE Journal
Cancer Research

This content is Open Access.

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
 

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Article doi: 10.3791/56327
September 8th, 2017

Summary September 8th, 2017

Resistance to cancer therapies contributes to disease progression and death. Determining the mechanistic underpinnings of resistance is crucial for improving therapeutic response. This manuscript details the protocol to generate taxane-resistant cell models of prostate cancer (PC) to help dissecting the pathways involved in progression to Docetaxel resistance in PC patients.

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