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JoVE Journal
Bioengineering
Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging

Full Text
12,196 Views
09:43 min
October 16, 2017

DOI: 10.3791/56649-v

Kathyayini Sivasubramanian1, Vijitha Periyasamy1, Manojit Pramanik1

1School of Chemical and Biomedical Engineering,Nanyang Technological University

Overview

This study demonstrates a clinical handheld photoacoustic imaging system for real-time, non-invasive imaging of small animals. The system integrates light illumination with a clinical ultrasound platform to achieve high-resolution imaging.

Key Study Components

Area of Science

  • Photoacoustic imaging
  • Ultrasound technology
  • Non-invasive imaging techniques

Background

  • Photoacoustic imaging combines light and ultrasound for enhanced imaging.
  • It offers high optical contrast and resolution for deep tissue imaging in vivo.
  • Translating this technology into clinical applications poses challenges.
  • Handheld systems can improve accessibility and usability in clinical settings.

Purpose of Study

  • To demonstrate non-invasive handheld photoacoustic imaging at the sentinel lymph node.
  • To illustrate real-time photoacoustic needle guidance.
  • To present a practical application of photoacoustic imaging in clinical settings.

Methods Used

  • Integration of light illumination with a clinical ultrasound system.
  • Real-time imaging and guidance techniques.
  • Use of a handheld device for imaging small animals.
  • Demonstration by trained researchers.

Main Results

  • Successful demonstration of real-time photoacoustic imaging.
  • Effective needle guidance using the photoacoustic system.
  • High-resolution imaging achieved with the handheld device.
  • Potential for clinical applications in non-invasive diagnostics.

Conclusions

  • The handheld photoacoustic imaging system shows promise for clinical use.
  • Real-time imaging capabilities enhance procedural accuracy.
  • Further research is needed to optimize the system for broader applications.

Frequently Asked Questions

What is photoacoustic imaging?
Photoacoustic imaging is a hybrid imaging modality that combines light and ultrasound to provide high-resolution images of tissues.
How does the handheld system work?
The system integrates light illumination with ultrasound technology to capture real-time images of small animals.
What are the benefits of using a handheld device?
Handheld devices improve accessibility and allow for non-invasive imaging in various clinical settings.
Who conducted the study?
The study was conducted by Kathyayini Sivasubramanian, a PhD student, and Vijitha Periyasamy, a researcher from the laboratory.
What challenges exist in clinical applications of photoacoustic imaging?
Translating photoacoustic imaging technology into clinical practice involves technical and practical challenges that need to be addressed.

A clinical handheld photoacoustic imaging system will be demonstrated for real-time non-invasive small animal imaging.

The overall goal of this procedure is to demonstrate non-invasive handheld photoacoustic imaging at the sentinel lymph node using a clinical ultrasound system and to illustrate real-time photoacoustic needle guidance. Photoacoustic imaging, hybrid imaging modality combining light and ultrasound provides high optical contrast, high resolution, deep tissue imaging in vivo. However, translating for the crystal imaging into clinical application is challenging.

This work presents a hand-held, real time, photoacoustic imaging system by integrating light illumination with the clinical ultrasound platform. Demonstrating the procedure will be Kathyayini Sivasubramanian a PHD student and Vijitha Periyasamy a researcher from our laboratory. Turn on the laser by switching on the AC power and turning the key on the laser controller to the left.

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