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Journal / Bioengineering / Vergleichbare Decellularization von fetalen und…
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Bioengineering

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JoVE Journal Bioengineering
Vergleichbare Decellularization von fetalen und adulten Herzgewebe Explantaten als 3D-ähnliche Plattformen für In-vitro-Studien
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Vergleichbare Decellularization von fetalen und adulten Herzgewebe Explantaten als 3D-ähnliche Plattformen für In-vitro-Studien

Article DOI: 10.3791/56924-v • 08:10 min • March 21st, 2019
March 21st, 2019 •
1,2,3,4, 1,2,5, 4,6, 1,2,3, 1,2, 1,2,3
1i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 2INEB - Instituto de Engenharia Biomédica, Universidade do Porto, 3Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, 4Gladstone Institute of Cardiovascular Disease, 5Faculty of Medicine, University of Porto, 6University of California San Francisco

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Die kardiale extrazelluläre Matrix (ECM) ist ein komplexes Netzwerk von Molekülen, die Schlüsselprozesse in Geweben und Organen zu orchestrieren, während dauerhafte physiologische Umbau lebenslang. Standardisierte Decellularization der fetalen und adulten Herzen ermöglicht vergleichende experimentelle Studien der beiden Gewebe in einem 3D Kontext durch die Erfassung von native Architektur und biomechanischen Eigenschaften.

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Biotechnik Ausgabe 145 Decellularization extrazelluläre Matrix 3D Gerüste fetalen Herzens Erwachsenen Herzen Herzgewebe Engineering
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