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Standardized Measurement of Nasal Membrane Transepithelial Potential Difference (NPD)
Standardized Measurement of Nasal Membrane Transepithelial Potential Difference (NPD)
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
Standardized Measurement of Nasal Membrane Transepithelial Potential Difference (NPD)

Standardized Measurement of Nasal Membrane Transepithelial Potential Difference (NPD)

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09:47 min

September 13, 2018

DOI:

09:47 min
September 13, 2018

16351 Views
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Summary

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Here, we present a standardized protocol to measure the nasal potential difference (NPD). Cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) function are evaluated by the change in the voltage across the nasal epithelium after superfusion of solutions that modify ion channel activity, providing an outcome measure.

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