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JoVE Journal
Medicine

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Standardized Measurement of Nasal Membrane Transepithelial Potential Difference (NPD)
 

Standardized Measurement of Nasal Membrane Transepithelial Potential Difference (NPD)

Article doi: 10.3791/57006
September 13th, 2018 Usage Statistics

Summary September 13th, 2018

Here, we present a standardized protocol to measure the nasal potential difference (NPD). Cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) function are evaluated by the change in the voltage across the nasal epithelium after superfusion of solutions that modify ion channel activity, providing an outcome measure.

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