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Developmental Biology

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Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
 

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Article doi: 10.3791/57157
April 3rd, 2018

Summary April 3rd, 2018

The goal of the protocol is to build an inflammatory human gingiva model in vitro. This tissue model co-cultivates three types of human cells, HaCaT keratinocytes, gingival fibroblasts, and THP-1 macrophages, under three-dimensional conditions. This model can be applied to investigating periodontal diseases, such as gingivitis and periodontitis.

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