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Genetics

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Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
 

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Article DOI: 10.3791/57442-v 11:13 min April 10th, 2018
April 10th, 2018

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Summary

As the genetic variants associated with human disease begin to become uncovered, it is becoming increasingly important to develop systems with which to rapidly evaluate the biological significance of those identified variants. This protocol describes methods for evaluating human gene function during female meiosis I using mouse oocytes.

Tags

Keywords: Mouse Oocytes Human Gene Function Meiosis I Maternal Aneuploidy In Vitro Fertilization Exome Sequencing Cloning Mutagenesis In Vitro Transcription Microinjection Milrinone Metaphase I
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