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Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method
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Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Article DOI: 10.3791/58599-v • 08:15 min • May 22nd, 2019
May 22nd, 2019 •
1, 2, 1, 1, 1,3, 1,4
1Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, 2Department of Medicine, Division of Nephrology, Rush University Medical Center, 3Department of Medicine, Division of Nephrology, The University of Mississippi Medical Center, 4Department of Neurology, The University of Mississippi Medical Center

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Summary
Automatic Translation

Estimates of whole kidney nephron number are important clinically and experimentally, as there is an inverse association between nephron number and an enhanced risk of renal and cardiovascular disease.Herein, the use of the acid maceration method, which provides fast and reliable estimates of whole kidney nephron number, is demonstrated.

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Acid Maceration Method Nephron Number Estimation Kidney Genes Nephron Development Diabetes Hypertension Renal Pathology Advantages Reproducible Inexpensive Time Consuming Magnetic Resonance Imaging Renal Function Pharmacological Approaches Genetic Approaches Surgical Scissors Mouse Abdominal Cavity
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