Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos

The toxicity testing procedures will be demonstrated by Dr.Ashok Aspatwar, a senior researcher from my laboratory. Our protocol identifies off-target effects and detects subtle toxic effects of chemicals in the early phase of discovery that may be missed in cell culture or other animal models. The main advantages of our technique are:it is rapid and efficient, requires very small amount of chemical, and the basic facilities in the laboratory.

Toxicity screening will help us in deciding the concentration for studying its efficiency against mycobacterium that causes tuberculosis and for further preclinical calculation. This method uses insights into off-target effects of chemicals, and hence this method can be used in any area of research where the toxicity of chemical is of primary importance. This method is very simple and can be carried out by anybody without prior experience.