Aneurysm Formation
Aneurysm Formation - Related Videos
03:47
A Murine Model of Carotid Aneurysm Formation
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2025
The present protocol describes a standardized surgical method for the induction of carotid aneurysms in a murine model through a single surgical operation.
08:51
A New Murine Model of Endovascular Aortic Aneurysm Repair
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Cited by 3 •
2013
Histological and biochemical modifications after aneurysm endograft exclusion are still unclear. We describe a new model of endograft implantation on a murine aneurysm. Through thrombus analysis with and without persistant circulating blood stream interface, and new endovascular biomaterials evaluation, this model will help to better understand endovascular aneurysm exclusion pathobiology.
01:26
Magnetic Resonance Imaging of Cerebral Aneurysms Using MPRAGE
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2025
Begin with a patient diagnosed with cerebral aneurysms, a condition where blood vessels in the brain bulge and fill with blood.Secure the patient’s head inside the head coil of an MRI machine. Initiate imaging. The system generates a strong magnetic field, aligning protons in the brain tissue along its direction. Initiate the magnetization-prepared rapid gradient echo or MPRAGE sequence by applying an inversion radiofrequency pulse, flipping the protons’ alignment opposite to the magnetic field.
13:53
The Helsinki Rat Microsurgical Sidewall Aneurysm Model
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Cited by 21 •
2014
Microsurgical sidewall aneurysms in rats are created by end-to-side anastomosis of an aortic graft to the abdominal aorta. We present step-by-step instructions and discuss anatomical and surgical details for successful experimental saccular aneurysm creation.
10:12
Near-infrared Fluorescence Imaging of Abdominal Aortic Aneurysms
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2023
Source: Arvin H. Soepriatna1, Kelsey A. Bullens2, and Craig J. Goergen1 1 Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 2 Department of Biochemistry, Purdue University, West Lafayette, Indiana Near-infrared fluorescence (NIRF) imaging is an exciting optical technique that utilizes fluorescent probes to visualize complex biomolecular assemblies in tissues. NIRF imaging has many advantages over conventional imaging methods for noninvasive imaging of diseases.
FAQs
Collagen and elastin provide structural strength and elasticity within the vessel wall. When these components lose strength, the wall becomes less able to withstand mechanical forces associated with blood flow. This loss of structural support promotes localized dilation and helps explain why vessel integrity is central to studying progression and rupture risk.
Inflammation and enzymatic tissue remodeling can further reduce vessel-wall stability after structural weakening begins. These processes alter the tissue environment and may accelerate the loss of supportive components. Examining them helps researchers connect cellular and biochemical responses with changes in vessel structure and the progression of abnormal dilation.
Altered blood flow changes the mechanical conditions experienced by the vessel wall. Together with weakened structural components and cellular responses, these forces can influence how localized dilation develops and progresses. Studying this relationship allows vascular biology research to examine disease as an interaction between tissue strength, blood-flow conditions, and mechanical stress.
A comprehensive investigation considers vessel structure, collagen and elastin strength, inflammation, enzymatic remodeling, altered blood flow, and cellular responses. These factors do not act as isolated observations; their interactions help determine wall stability and disease progression. Evaluating them together supports more informative biological models and helps identify potential risk factors.
Imaging and monitoring strategies help researchers investigate vessel structure and follow changes associated with progression. Their value lies in connecting biological mechanisms, such as wall weakening and localized dilation, with observable changes over time. This information can support efforts to identify risk factors, assess disease development, and guide investigation of treatment strategies.
The topic links molecular and cellular events with whole-vessel behavior and clinically important outcomes. Research examines how structural components, cellular responses, inflammation, enzymatic remodeling, and mechanical forces interact within blood vessels. This context supports the development of strategies for imaging, monitoring, and treatment while improving understanding of vascular disease progression and rupture.