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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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1Department of Neurology and Neuropathology,Golgi-Cenci Foundation, 2Laboratory of Neurobiology and Neurogenetic,Golgi-Cenci Foundation, 3Department of Neuropsychology and Social Sciences,Golgi-Cenci Foundation, 4Department of Rehabilitation,ASP Golgi-Redaelli Geriatric Hospital, 5Genomic and Post-Genomic Center,IRCCS Mondino Foundation, 6Department of Brain and Behavioral Sciences,University of Pavia, 7Department of Pathology,ASP Golgi-Redaelli Geriatric Hospital, 8Department of Neurological Science, IRCCS Mondino Foundation,University of Pavia
Chapters
- 00:04Introduction
- 01:28Time of Death and Brain Removal
- 05:23Abbiategrasso Brain Bank (ABB) Dissection
- 08:26Tissue Freezing and Fixation
- 09:17Results: Representative Brain Specimen Characterization and Analyses
- 11:13Conclusion
This protocol describes a method to track individual brain-aging trajectories through a brain donation program and proper characterization of brains. Brain donors are involved in a long-term longitudinal study including serial multi-dimensional assessments. The protocol contains a detailed description of brain processing and an accurate diagnostic methodology.
Tags
Keywords:
Brain BankAging BrainNeurocognitive DisorderNeuropathological FindingsDefinite DiagnosisBrain DamageMultiple PathologiesFresh Cutting ProceduresMacro Section ManagementThanatographyScalp IncisionSkull CapMeningesCerebral Spinal FluidBrain HarvestNeurodegenerative MechanismsDeep LearningPathogenesisTherapiesDuraCorpus CallosumThird Ventricle
