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JoVE Journal
Neuroscience

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Microinjectrode System for Combined Drug Infusion and Electrophysiology
 

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Article DOI: 10.3791/60365-v 08:30 min November 13th, 2019
November 13th, 2019

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Summary

We present a microinjectrode system designed for electrophysiology and assisted delivery of experimental probes (i.e., nanosensors, microelectrodes), with optional drug infusion. Widely available microfluidic components are coupled to a cannula containing the probe. A step-by-step protocol for microinjectrode construction is included, with results during muscimol infusion in macaque cortex.

Tags

Microinjectrode System Drug Infusion Electrophysiology Experimental Probes Microelectrodes Nanosensors Awake Behaving Animals Cannula Dura Mater Microfluidic Infusion Nanoliter Scale Probe Insertion T Junction Ferrule Tubing
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