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Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents
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1Geriatrics Research Education and Clinical Center,Veterans Affairs, 2Division of Gerontology and Geriatric Medicine,University of Washington, 3Department of Neurosurgery,University of Florida, 4Department of Neurosurgery,West Virginia University, 5Division of Pharmaceutical Sciences,University of Cincinnati, 6Central Illinois Neuro Health Sciences, Bloomington, IL, 7Neuro-research, Dallas, TX
Chapters
- 00:04Introduction
- 00:53Installation of the Blast TBI Setup
- 01:34Preparation of Experimental Setup and Induction of Mild TBI in Rodents
- 03:06Exposure of Rodent to Blast Wave and its Recovery
- 03:59Results: Acute In-Vivo Effects of Blast-Induced TBI
- 05:28Conclusion
We present here a protocol of a blast wave model for rodents to investigate neurobiological and pathophysiological effects of mild to moderate traumatic brain injury. We established a gas-driven, bench-top setup equipped with pressure sensors allowing for reliable and reproducible generation of blast-induced mild to moderate traumatic brain injury.
