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Neuroscience

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A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
 

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Article DOI: 10.3791/61269-v 08:02 min July 16th, 2020
July 16th, 2020

Summary

The blood-brain barrier (BBB) can be temporarily disrupted with microbubble-mediated focused ultrasound (FUS). Here, we describe a step-by-step protocol for high-throughput BBB opening in vivo using a modular FUS system accessible for non-ultrasound experts.

Transcript

Tags

High-throughput Image-guided Stereotactic Neuronavigation Focused Ultrasound System Blood-brain Barrier Opening Rodents High-grade Gliomas Diffused Intrinsic Pontine Glioma Invasive Tumors Mortality Chemotherapy Effective Treatments Neuro-navigated Cost-effective Preclinical Drug Evaluation Studies Precision Medicine Right Drug Right Dose Right Patient Right Time Preselected Drugs Screening Compact High-throughput Focused Ultrasound System Image-guided Stereotactic Neuro-navigation Focused Ultrasound Procedure
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