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Behavior

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Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats
 

Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats

Article DOI: 10.3791/61743
May 27th, 2021

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Summary May 27th, 2021

We present protocols for generating acute and chronic experimental models of tic expression in freely behaving rats. The models are based on striatal cannula implantation and subsequent GABAA antagonist application. The acute model uses transient injections whereas the chronic model utilizes prolonged infusions via a subcutaneous implanted mini-osmotic pump.

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