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Journal / Bioengineering / Herzsphäroide als in vitro bioengineered…
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Bioengineering
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JoVE Journal Bioengineering
Herzsphäroide als in vitro bioengineered Herzgewebe zur Untersuchung der menschlichen Herzpathophysiologie
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Herzsphäroide als in vitro bioengineered Herzgewebe zur Untersuchung der menschlichen Herzpathophysiologie

Article DOI: 10.3791/61962-v • 10:41 min • January 23rd, 2021
January 23rd, 2021 •
1,2,3,4, 2,3,4
1University of Newcastle, 2University of Sydney, 3Kolling Institute of Medical Research, Royal North Shore Hospital, 4University of Technology, Sydney

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Dieses Protokoll zielt darauf ab, 3D-Herzsphäroide (CSs) zu fabrizieren, indem Zellen in hängenden Tropfen mitgebaut werden. Kollagen-eingebettete CS werden mit Doxorubicin (DOX, einem kardiotoxischen Mittel) in physiologischen Konzentrationen behandelt, um Herzinsuffizienz zu modellieren. In-vitro-Tests mit DOX-behandelten CS können verwendet werden, um neuartige Therapien für Herzinsuffizienz-Patienten zu identifizieren.

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Bioengineering Ausgabe 167 Vaskuläre Herzsphäride bioengineered Herzgewebe Vaskularisation 3D-Kokulturen Stammzellen Kardiomyozyten Fibroblasten Endothelzellen In-vitro-Tests Doxorubicin Kardiotoxizität.
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