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Journal / Bioengineering / Toksisitetsskjermer i humane retinale organoider…
JoVE Journal
Bioengineering

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JoVE Journal Bioengineering
Toksisitetsskjermer i humane retinale organoider for farmasøytisk oppdagelse
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Toksisitetsskjermer i humane retinale organoider for farmasøytisk oppdagelse

Article DOI: 10.3791/62269-v • 07:45 min • March 4th, 2021
March 4th, 2021 •
1,2, 1,2, 1,2, 1,2
1Lowy Medical Research Institute, 2The Scripps Research Institute

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Her presenterer vi en trinnvis protokoll for å generere modne humane retinale organoider og bruke dem i en fotoreceptortoksisitetsanalyse for å identifisere farmasøytiske kandidater for den aldersrelaterte retinale degenerative sykdommen makulærtelangiektasi type 2 (MacTel).

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Denne måneden i JoVE utgave 169 retinal organoid organoid retinal degenerasjon MacTel sfingolipid fotoreseptor fenofibrat TUNEL farging narkotika skjerm lipid toksisitet
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