Journal
/
Biology
/
Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
JoVE Journal
Biology
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Biology
Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH

DOI:
10.3791/62403-v

•

07:13 min

•

April 20, 2021

•

, , , , ,
1Comparative Medicine,Pfizer Inc., 2Digital Medicine & Translational Imaging,Pfizer Inc., 3Internal Medicine Research Unit,Pfizer Inc., 4Drug Safety Research & Development,Pfizer Inc.

Chapters

  • 00:05Introduction
  • 00:40Preparation of Rat for Imaging and Instrument Set-up
  • 02:01Image Acquisition for Hepato-Renal (HR) Index Measurement
  • 03:27Image Acquisition for the Shear Wave Elastography
  • 04:43Image Data Retrieval
  • 05:12Results: Analysis of the Hepato-renal Index and Shear Wave Elastography in High-fat and Control Diet Groups
  • 06:37Conclusion

Summary

Automatic Translation

Automatic Translation

This protocol describes the use of an enhanced ultrasound technique to non-invasively observe and quantify liver tissue changes in rodent models of nonalcoholic fatty liver disease.

Tags

Keywords: UltrasoundShear Wave ElastographyNAFLDNASHRat ModelNon-invasiveHigh-throughputDrug DiscoveryCholine Deficient High-fat DietAnesthesiaChemical DepilationB-mode ImagingRenal CortexLiver Parenchyma

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

check_url/62403?article_type=v

Use of Rotorod as a Method for the Qualitative Analysis of Walking in Rat
check_url/62403?article_type=v

Implantation of Engineered Tissue in the Rat Heart
check_url/62403?article_type=v

Imaging of Estrogen Receptor-α in Rat Pial Arterioles using a Digital Immunofluorescent Microscope
check_url/62403?article_type=v

Isolation and Primary Culture of Rat Hepatic Cells
check_url/62403?article_type=v

Rat Mesentery Exteriorization: A Model for Investigating the Cellular Dynamics Involved in Angiogenesis
check_url/62403?article_type=v

High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately
check_url/62403?article_type=v

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
check_url/62403?article_type=v

Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging
check_url/62403?article_type=v

High-resolution Time-lapse Imaging and Automated Analysis of Microtubule Dynamics in Living Human Umbilical Vein Endothelial Cells
check_url/62403?article_type=v

The Assembly and Application of ‘Shear Rings’: A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

Read Article