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JoVE Journal Cancer Research
Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
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Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Article DOI: 10.3791/62683-v • 09:57 min • June 28th, 2021
June 28th, 2021 •
1,2, 3,4, 1,4,5,6, 3,4, 1,2,3,5,6,7
1Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, 2Department of Pathology, University of Iowa, 3Department of Chemical and Biological Engineering, College of Engineering, Iowa State University, 4Nanovaccine Institute, Iowa State University, 5Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, 6Holden Comprehensive Cancer Center, University of Iowa, 7Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa

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Summary
Automatic Translation

A standard protocol is described to study the antitumor activity and associated toxicity of IL-1α in a syngeneic mouse model of HNSCC.

Tags

Immunotherapeutic Strategy Cytokine Therapy IL-1 Alpha Antitumor Activity Polyanhydride Nanoparticles Controlled Release Toxic Side Effects Head And Neck Squamous Cell Carcinoma Mouse Model IL-1a-loaded Nanoparticles Tumor Size Body Weight Antitumor Immunity
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