Balaji Narasimhan

Department of Chemical and Biological Engineering, Iowa State University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 5	Year
Publication title Cited by 7	2012
Publication title Cited by 16	2012
Publication title Cited by 60	2012
Publication title Cited by 7	2012
Publication title Cited by 1	2021

Other Publications

Article	Year
Mechanistic relationships between polymer microstructure and drug release kinetics in bioerodible polyanhydrides. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 12106982	2002
Design of an injectable system based on bioerodible polyanhydride microspheres for sustained drug delivery. Biomaterials\| PubMed ID: 12219831	2002
Microsphere size, precipitation kinetics and drug distribution control drug release from biodegradable polyanhydride microspheres. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 14684277	2004
Encapsulation, stabilization, and release of BSA-FITC from polyanhydride microspheres. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 15491814	2004
Synthesis and characterization of novel polyanhydrides with tailored erosion mechanisms. Journal of biomedical materials research. Part A\| PubMed ID: 16138330	2006
Characterization of fate and transport of isoxaflutole, a soil-applied corn herbicide, in surface water using a watershed model. Journal of agricultural and food chemistry\| PubMed ID: 16248595	2005
Parallel synthesis and high throughput dissolution testing of biodegradable polyanhydride copolymers. Journal of combinatorial chemistry\| PubMed ID: 16283803	2005
Single dose vaccine based on biodegradable polyanhydride microspheres can modulate immune response mechanism. Journal of biomedical materials research. Part A\| PubMed ID: 16345084	2006
Problem-based learning biotechnology courses in chemical engineering. Biotechnology progress\| PubMed ID: 16454508	2006
Protein stability in the presence of polymer degradation products: consequences for controlled release formulations. Biomaterials\| PubMed ID: 16504288	2006
Amphiphilic polyanhydrides for protein stabilization and release. Biomaterials\| PubMed ID: 16965812	2007
The role of microsphere fabrication methods on the stability and release kinetics of ovalbumin encapsulated in polyanhydride microspheres. Journal of microencapsulation\| PubMed ID: 17390625	2006
Immunomodulatory biomaterials. International journal of pharmaceutics\| PubMed ID: 18662761	2008
Vaccine adjuvants: current challenges and future approaches. Journal of pharmaceutical sciences\| PubMed ID: 18704954	2009
Combinatorial design of biomaterials for drug delivery: opportunities and challenges. Expert opinion on drug delivery\| PubMed ID: 18712994	2008
Polymer chemistry influences monocytic uptake of polyanhydride nanospheres. Pharmaceutical research\| PubMed ID: 18987960	2009
Cobalt ferrite nanocrystals: out-performing magnetotactic bacteria. ACS nano\| PubMed ID: 19206653	2007
High throughput cell-based screening of biodegradable polyanhydride libraries. Combinatorial chemistry & high throughput screening\| PubMed ID: 19531023	2009
The simultaneous effect of polymer chemistry and device geometry on the in vitro activation of murine dendritic cells. Biomaterials\| PubMed ID: 19539989	2009
Effect of polymer chemistry and fabrication method on protein release and stability from polyanhydride microspheres. Journal of biomedical materials research. Part B, Applied biomaterials\| PubMed ID: 19642209	2009
Combinatorial/high throughput methods for the determination of polyanhydride phase behavior. Journal of combinatorial chemistry\| PubMed ID: 19691268	2009
Tracking chemical processing pathways in combinatorial polymer libraries via data mining. Journal of combinatorial chemistry\| PubMed ID: 20030378	2010
Encapsulation into amphiphilic polyanhydride microparticles stabilizes Yersinia pestis antigens. Acta biomaterialia\| PubMed ID: 20123135	2010
Lipocalin-2-loaded Amphiphilic Polyanhydride Microparticles Accelerate Cell Migration. Journal of biomaterials science. Polymer edition\| PubMed ID: 20615357	2010
Protein adsorption on biodegradable polyanhydride microparticles. Journal of biomedical materials research. Part A\| PubMed ID: 20740599	2010
Mathematical modeling of polymer erosion: consequences for drug delivery. International journal of pharmaceutics\| PubMed ID: 21130849	2011
Identifying factors controlling protein release from combinatorial biomaterial libraries via hybrid data mining methods. ACS combinatorial science\| PubMed ID: 21247125	2011
Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseases. PloS one\| PubMed ID: 21408610	2011
Polyanhydride microparticles enhance dendritic cell antigen presentation and activation. Acta biomaterialia\| PubMed ID: 21439412	2011
A novel high throughput method to investigate polymer dissolution. Macromolecular rapid communications\| PubMed ID: 21590918	2010
Amphiphilic polyanhydride films promote neural stem cell adhesion and differentiation. Tissue engineering. Part A\| PubMed ID: 21599544	2011
Activation of innate immune responses in a pathogen-mimicking manner by amphiphilic polyanhydride nanoparticle adjuvants. Biomaterials\| PubMed ID: 21703679	2011
Mannose-functionalized "pathogen-like" polyanhydride nanoparticles target C-type lectin receptors on dendritic cells. Molecular pharmaceutics\| PubMed ID: 21882825	2011
Rational design of pathogen-mimicking amphiphilic materials as nanoadjuvants. Scientific reports\| PubMed ID: 22355713	2011
Tailoring the immune response by targeting C-type lectin receptors on alveolar macrophages using "pathogen-like" amphiphilic polyanhydride nanoparticles. Biomaterials\| PubMed ID: 22465338	2012
Chemistry-dependent adsorption of serum proteins onto polyanhydride microparticles differentially influences dendritic cell uptake and activation. Acta biomaterialia\| PubMed ID: 22684115	2012
Single immunization with a suboptimal antigen dose encapsulated into polyanhydride microparticles promotes high titer and avid antibody responses. Journal of biomedical materials research. Part B, Applied biomaterials\| PubMed ID: 23143744	2013
Characterizing the antitumor response in mice treated with antigen-loaded polyanhydride microparticles. Acta biomaterialia\| PubMed ID: 23153760	2013
Block copolymer-quantum dot micelles for multienzyme colocalization. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 23171402	2012
Evaluation of biocompatibility and administration site reactogenicity of polyanhydride-particle-based platform for vaccine delivery. Advanced healthcare materials\| PubMed ID: 23184561	2013
Retention of structure, antigenicity, and biological function of pneumococcal surface protein A (PspA) released from polyanhydride nanoparticles. Acta biomaterialia\| PubMed ID: 23774257	2013
Functionalization of polyanhydride microparticles with di-mannose influences uptake by and intracellular fate within dendritic cells. Acta biomaterialia\| PubMed ID: 23796408	2013
Combinatorial evaluation of in vivo distribution of polyanhydride particle-based platforms for vaccine delivery. International journal of nanomedicine\| PubMed ID: 23818778	2013
Multifunctional nanoparticles for targeted delivery of immune activating and cancer therapeutic agents. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24140748	2013
Materials-based strategies for multi-enzyme immobilization and co-localization: A review. Biotechnology and bioengineering\| PubMed ID: 24142707	2014
Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics. Advanced healthcare materials\| PubMed ID: 24376136	2014
A systems approach to designing next generation vaccines: combining α-galactose modified antigens with nanoparticle platforms. Scientific reports\| PubMed ID: 24441019	2014
Structural and antigenic stability of H5N1 hemagglutinin trimer upon release from polyanhydride nanoparticles. Journal of biomedical materials research. Part A\| PubMed ID: 24443139	2014
Lung deposition and cellular uptake behavior of pathogen-mimicking nanovaccines in the first 48 hours. Advanced healthcare materials\| PubMed ID: 24520022	2014
Mathematical models in drug delivery: how modeling has shaped the way we design new drug delivery systems. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24998939	2014
Effect of nanovaccine chemistry on humoral immune response kinetics and maturation. Nanoscale\| PubMed ID: 25285425	2014
Pulmonary biodistribution and cellular uptake of intranasally administered monodisperse particles. Pharmaceutical research\| PubMed ID: 25297714	2015
Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles. The AAPS journal\| PubMed ID: 25421457	2015
Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity. International journal of nanomedicine\| PubMed ID: 25565816	2015
Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 25645958	2015
Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 25652894	2015
Nano-enabled delivery of diverse payloads across complex biological barriers. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26315817	2015
Respiratory nanoparticle-based vaccines and challenges associated with animal models and translation. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26410807	2015
Polyanhydride Nanoparticle Delivery Platform Dramatically Enhances Killing of Filarial Worms. PLoS neglected tropical diseases\| PubMed ID: 26496201	2015
Rational Design of Targeted Next-Generation Carriers for Drug and Vaccine Delivery. Annual review of biomedical engineering\| PubMed ID: 26789697	2016
Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 26838361	2016
Polyanhydride Nanovaccines Induce Germinal Center B Cell Formation and Sustained Serum Antibody Responses. Journal of biomedical nanotechnology\| PubMed ID: 27319223	2016
Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 27771430	2016
Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous cell-mediated immune response in pigs. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 28057521	2017
The effect of polyanhydride chemistry in particle-based cancer vaccines on the magnitude of the anti-tumor immune response. Acta biomaterialia\| PubMed ID: 28063991	2017
Polyanhydride nanovaccine against swine influenza virus in pigs. Vaccine\| PubMed ID: 28117173	2017
Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxidants & redox signaling\| PubMed ID: 28375739	2017
Functionalization promotes pathogen-mimicking characteristics of polyanhydride nanoparticle adjuvants. Journal of biomedical materials research. Part A\| PubMed ID: 28556563	2017
Intestinal organoids containing poly(lactic-co-glycolic acid) nanoparticles for the treatment of inflammatory bowel diseases. Journal of biomedical materials research. Part A\| PubMed ID: 29226615	2018
Emerging trends in the immunotherapy of pancreatic cancer. Cancer letters\| PubMed ID: 29242097	2018
Ligand-cascading nano-delivery devices to enable multiscale targeting of anti-neurodegenerative therapeutics. Biomedical materials (Bristol, England)\| PubMed ID: 29332842	2018
A single dose polyanhydride-based vaccine platform promotes and maintains anti-GnRH antibody titers. Vaccine\| PubMed ID: 29413092	2018
A polyanhydride-based implantable single dose vaccine platform for long-term immunity. Vaccine\| PubMed ID: 29413093	2018
pH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles. Biomacromolecules\| PubMed ID: 29443509	2018
Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf. Scientific reports\| PubMed ID: 29445124	2018
Room Temperature Stable PspA-Based Nanovaccine Induces Protective Immunity. Frontiers in immunology\| PubMed ID: 29599766	2018
Automated High-Throughput Synthesis of Protein-Loaded Polyanhydride Nanoparticle Libraries. ACS combinatorial science\| PubMed ID: 29617113	2018
Intranasal delivery of influenza antigen by nanoparticles, but not NKT-cell adjuvant differentially induces the expression of B-cell activation factors in mice and swine. Cellular immunology\| PubMed ID: 29665972	2018
Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections. Frontiers in immunology\| PubMed ID: 30233573	2018
Single Dose of a Polyanhydride Particle-Based Vaccine Generates Potent Antigen-Specific Antitumor Immune Responses. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 30361239	2019
Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. Journal of biomedical materials research. Part A\| PubMed ID: 30369055	2018
Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases. International journal of pharmaceutics\| PubMed ID: 30448309	2019
Surface engineered polyanhydride-based oral subunit nanovaccine for poultry. International journal of nanomedicine\| PubMed ID: 30555234	2018
Nanotherapeutic provides dose sparing and improved antimicrobial activity against Brucella melitensis infections. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 30572034	2019
Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice. Biomaterials science\| PubMed ID: 30663733	2019
Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma. Journal for immunotherapy of cancer\| PubMed ID: 30890189	2019
Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of infection. Beilstein journal of organic chemistry\| PubMed ID: 30931004	2019
Safety and biocompatibility of injectable vaccine adjuvants composed of thermogelling block copolymer gels. Journal of biomedical materials research. Part A\| PubMed ID: 30972906	2019
STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice. Vaccine\| PubMed ID: 30987850	2019
Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells. Genes & cancer\| PubMed ID: 31258832	2019
Effective mosaic-based nanovaccines against avian influenza in poultry. Vaccine\| PubMed ID: 31300285	2019
Pentaerythritol-based lipid A bolsters the antitumor efficacy of a polyanhydride particle-based cancer vaccine. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 31319179	2019
Sustained antigen release polyanhydride-based vaccine platform for immunization against bovine brucellosis. Heliyon\| PubMed ID: 31517098	2019
Single-dose combination nanovaccine induces both rapid and long-lived protection against pneumonic plague. Acta biomaterialia\| PubMed ID: 31610342	2019
Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves. Scientific reports\| PubMed ID: 31641172	2019
Development of a subcutaneous ear implant to deliver an anaplasmosis vaccine to dairy steers. Journal of animal science\| PubMed ID: 31889177	2020
High-Throughput Synthesis and Screening of Rapidly Degrading Polyanhydride Nanoparticles. ACS combinatorial science\| PubMed ID: 32125826	2020
A single dose polyanhydride-based nanovaccine against paratuberculosis infection. NPJ vaccines\| PubMed ID: 32128256	2020
Chitosan-adjuvanted Salmonella subunit nanoparticle vaccine for poultry delivered through drinking water and feed. Carbohydrate polymers\| PubMed ID: 32532387	2020
Polyanhydride nanoparticles stabilize pancreatic cancer antigen MUC4β. Journal of biomedical materials research. Part A\| PubMed ID: 32776461	2021
Biodistribution of degradable polyanhydride particles in Aedes aegypti tissues. PLoS neglected tropical diseases\| PubMed ID: 32898130	2020
Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8 T Cell Memory and Delayed Tumor Progression. International journal of nanomedicine\| PubMed ID: 32982219	2020
Corrigendum to: Development of a subcutaneous ear implant to deliver an anaplasmosis vaccine to dairy steers. Journal of animal science\| PubMed ID: 33151332	2020
Polymeric Nanoparticle-Based Vaccine Adjuvants and Delivery Vehicles. Current topics in microbiology and immunology\| PubMed ID: 33165869	2020
Enzyme Immunoassay-Based Platform for Accurate Detection of Serum Pathological α-Synuclein in Parkinson's Disease Patients. ACS chemical neuroscience\| PubMed ID: 33196164	2020
Applications of Nanovaccines for Disease Prevention in Cattle. Frontiers in bioengineering and biotechnology\| PubMed ID: 33363134	2020
Pentablock Copolymer Micelle Nanoadjuvants Enhance Cytosolic Delivery of Antigen and Improve Vaccine Efficacy while Inducing Low Inflammation. ACS biomaterials science & engineering\| PubMed ID: 33405651	2019
Polyanhydride Nanoparticle Interactions with Host Serum Proteins and Their Effects on Bone Marrow Derived Macrophage Activation. ACS biomaterials science & engineering\| PubMed ID: 33450792	2017
Synthesis and Characterization of Rapidly Degrading Polyanhydrides as Vaccine Adjuvants. ACS biomaterials science & engineering\| PubMed ID: 33463223	2020
A single dose polyanhydride-based nanovaccine against paratuberculosis infection. NPJ vaccines\| PubMed ID: 33580082	2020
Prefusion F-Based Polyanhydride Nanovaccine Induces Both Humoral and Cell-Mediated Immunity Resulting in Long-Lasting Protection against Respiratory Syncytial Virus. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 33827894	2021
Single-dose combination nanovaccine induces both rapid and durable humoral immunity and toxin neutralizing antibody responses against Bacillus anthracis. Vaccine\| PubMed ID: 34090702	2021