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Journal / Bioengineering / Subretinale Implantation von RPE auf einem Träger …
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Bioengineering
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JoVE Journal Bioengineering
Subretinale Implantation von RPE auf einem Träger bei Minipigs
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Subretinale Implantation von RPE auf einem Träger bei Minipigs: Leitlinien für präoperative Vorbereitungen, Operationstechniken und postoperative Versorgung

Article DOI: 10.3791/63505-v • 11:06 min • November 11th, 2022
November 11th, 2022 •
*1,2, *3, 4, 4, 4, 5,6, 5,6, 5,6, 5,6, 5,6, 5, 5, 5, 5, 7, 8, 9, 10, 11, 1, 1, 5, *8, *5
1Eye Clinic, Department of Ophthalmology, University Hospital Giessen and Marburg GmbH, 2Karl Landsteiner Institute for Retinal Research and Imaging, 3Department of Ophthalmology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University in Prague, 4Institute of Macromolecular Chemistry, Czech Academy of Sciences, 5Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 6Department of Cell Biology, Faculty of Science, Charles University, 7Institute of Experimental Medicine, Czech Academy of Sciences, 8Center for Eye Research, Department of Ophthalmology, Oslo University Hospital and Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 9Moorfields Eye Hospitals UAE, 10Stem Cell Therapies in Neurodegenerative Diseases Lab, Research Center “Principe Felipe”, 11Eye Center Donaustadt, Department of Ophthalmology, Sigmund Freud University
* These authors contributed equally

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Die subretinale Implantation von retinalem Pigmentepithel (RPE) ist einer der vielversprechendsten Ansätze zur Behandlung degenerativer Netzhauterkrankungen. Die Leistung präklinischer Studien an großäugigen Tiermodellen bleibt jedoch eine Herausforderung. In diesem Bericht werden Leitlinien für die subretinale Transplantation von RPE auf einem Zellträger in Minischweine vorgestellt.

Tags

Bioengineering Heft 189 Altersbedingte Makuladegeneration retinales pigmentiertes Epithel RPE Großaugen-Tiermodell Minischweine Pars-plana-Vitrektomie PPV Zellträger In-vivo-Chirurgie prä- und postoperative Versorgung
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