Journal
/
Neuroscience
/
Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain
JoVE Journal
Neuroscience
Author Produced
This content is Free Access.
JoVE Journal Neuroscience
Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain

Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain

DOI:
10.3791/64079-v

•

08:23 min

•

March 31, 2023

•

, , , , , , , , , , , , ,
1Department of Neurosurgery,Houston Methodist Research Institute, 2ClearPoint Neuro, 3Translational Imaging Center,Houston Methodist Research Institute

Chapters

  • 00:15Introduction
  • 00:55Animal Positioning
  • 01:31Planning Surgical Insertion with MRI-Assisted Visualization Guidance
  • 02:24Securing the Stereotactic Frame and Adjusting Alignment Iteratively Through Software Projection
  • 03:55Drilling and Inserting the Cannula for Infusion
  • 05:41Monitoring the Infusion with Repeated MRI Scans
  • 06:31Representative Results
  • 07:15Conclusion

Summary

Automatic Translation

Automatic Translation

The protocol presented here demonstrates stereotaxy to the pig brain using convection-enhanced infusions, with real-time magnetic resonance imaging (MRI) visualization guidance and real-time infusion distribution visualization.

Tags

Keywords: Magnetic Resonance ImagingStereotaxyInfusionPig BrainNeurosurgical InterventionMRI-guided ProcedureAnimal PositioningSurgical PlanningStereotactic FrameTrajectory PlanningEntry PointTarget Point

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

check_url/64079?article_type=v

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
check_url/64079?article_type=v

State-Dependency Effects on TMS: A Look at Motive Phosphene Behavior
check_url/64079?article_type=v

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
check_url/64079?article_type=v

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo
check_url/64079?article_type=v

Exposure of the Pig CNS for Histological Analysis: A Manual for Decapitation, Skull Opening, and Brain Removal
check_url/64079?article_type=v

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
check_url/64079?article_type=v

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
check_url/64079?article_type=v

In Vivo Single-Molecule Tracking at the Drosophila Presynaptic Motor Nerve Terminal
check_url/64079?article_type=v

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
check_url/64079?article_type=v

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Read Article