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Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model
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Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model

Article DOI: 10.3791/64177-v • 07:20 min • February 10th, 2023
February 10th, 2023 •
*1,2, *1, 1,2, 1, 2, 2, 2, 2, 3, 4, 2, 2, 1,2, 1,2
1Centre for Heart Research, The Westmead Institute for Medical Research, The University of Sydney, 2Department of Cardiology, Westmead Hospital, 3Sydney Imaging, Core Research Facility, The University of Sydney, 4Department of Cardiothoracic Surgery, Liverpool Hospital
* These authors contributed equally

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Summary
Automatic Translation

The present protocol describes three methods of administering cardioactive therapeutic agents in a porcine model. Female landrace swine received treatment through either: (1) thoracotomy and transepicardial injection, (2) catheter-based transendocardial injection, or (3) intravenous infusion via jugular vein osmotic minipump.

Tags

Cardioactive Therapeutics Myocardial Infarction Drug Delivery Porcine Model Large Animal Models Therapeutic Administration Swine Preclinical Evaluation Novel Agents Thoracotomy Transepicardial Injection Catheter-based Transendocardial Injection Intravenous Infusion Jugular Vein Osmotic Minipump Reproducible Procedures Reliable Drug Delivery Translational Science
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