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Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model
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Medicine
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JoVE Journal Medicine
Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model

Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model

DOI:
10.3791/64177-v

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07:20 min

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February 10, 2023

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, , , , , , , , , , , , ,
1Centre for Heart Research, The Westmead Institute for Medical Research,The University of Sydney, 2Department of Cardiology,Westmead Hospital, 3Sydney Imaging, Core Research Facility,The University of Sydney, 4Department of Cardiothoracic Surgery,Liverpool Hospital

Chapters

  • 00:05Introduction
  • 01:05Drug or Cell Administration
  • 06:19Results: Administration of Cardioactive Therapeutic Agents in a Porcine Model
  • 06:37Conclusion

Summary

Automatic Translation

Automatic Translation

The present protocol describes three methods of administering cardioactive therapeutic agents in a porcine model. Female landrace swine received treatment through either: (1) thoracotomy and transepicardial injection, (2) catheter-based transendocardial injection, or (3) intravenous infusion via jugular vein osmotic minipump.

Tags

AI-assisted Drug DeliveryIntramyocardial InjectionCardiac RepairMyocardial Infarction ModelPorcine Surgical ProcedureThoracotomyEpicardial Cell InjectionVeterinary AnesthesiaElectroanatomic MappingIntercostal Muscle Block

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