Drug Delivery
Drug Delivery - Related Videos
02:37
Ophthalmic Drug Delivery for Noninvasive Neuromodulation in a Mouse Model
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2025
Source: Zhan, J., et al. Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity. J. Vis. Exp. (2019)This video demonstrates a non-invasive ophthalmic drug delivery method for targeted neuromodulation. The drug is delivered via eye drops, absorbed into the circulation, crosses the blood-brain barrier, and activates specific neuronal receptors.
05:53
Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
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Cited by 5 •
2016
After puncturing the aorta through the inferior vena cava (IVC) to create an aorto-caval fistula in the mouse, solution containing a drug is infused into the IVC via the same needle, followed by incubation. This method enables more robust drug delivery to the venous endothelium compared to the external route.
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Cited by 49 •
2016
Nanoparticles are emerging as promising drug delivery systems for a broad range of indications. Here, we describe a simple yet powerful method to manufacture silk nanoparticles using reverse engineered Bombyx mori silk. These silk nanoparticles can be readily loaded with a therapeutic payload and subsequently explored for drug delivery applications.
03:37
Intranasal Drug Administration in Mice via Pipette and Reverse-Cannulation for Nose-to-Brain Drug Delivery
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2025
Source: Kanazawa, T., et al. Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery. J. Vis. Exp. (2018)This video demonstrates the intranasal administration of radiolabeled drugs in an anesthetized mouse to achieve nose-to-brain drug delivery. It explains how drugs cross the nasal epithelium and travel via neuronal pathways to reach the brain, as well as how ciliary motion influences drug retention and clearance. Additionally, the video...
04:36
Canalostomy for Local Drug Delivery into the Inner Ear of an Adult Mouse
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2025
This video showcases canalostomy, a procedure that allows local drug delivery into the inner ear of a mouse through the semicircular canal with minimal damage to hearing and vestibular function. This method enables the inoculation of viral vectors, pharmaceuticals, and small molecules into the mouse's inner ear.
FAQs
Design begins by aligning the therapeutic agent’s properties with a formulation, carrier, and administration route. This matching can influence whether the agent remains stable, is absorbed appropriately, distributes toward the intended tissue, and penetrates that tissue. Consequently, delivery design is not separate from drug performance; it helps determine how much therapeutic effect reaches the relevant biological location.
Release behavior depends on the mechanism built into the delivery system. A therapeutic agent may leave through diffusion, become available as the carrier degrades, or be released after a trigger associated with local conditions. Controlling this behavior helps regulate exposure over time and can connect drug availability with the biological environment at the intended site.
Nanoparticles, liposomes, implants, and targeted molecular carriers provide different design options for transporting an agent. The appropriate choice depends on the drug’s properties and the desired site of action, rather than on the carrier label alone. This comparison helps researchers select a system that supports stability, tissue penetration, or controlled release when those outcomes are needed.
A practical design workflow starts by identifying the therapeutic agent, intended biological site, and desired exposure pattern. Researchers then select a formulation, carrier, and administration route that fit those requirements, followed by choosing a release mechanism such as diffusion, degradation, or a local trigger. The resulting system can be considered through its stability, absorption, distribution, penetration, and release behavior.
In biology, these systems support more than conventional small-molecule treatment. They can transport nucleic acids and proteins, contribute to vaccine delivery, and support tissue-engineering strategies. Each application presents a distinct delivery challenge because the system must maintain cargo stability while helping it reach the relevant biological location with useful exposure and release.
By shaping where and when an agent becomes available, a delivery system can alter the balance between therapeutic benefit and unwanted exposure. Improved stability, absorption, distribution, or tissue penetration may increase the amount reaching the intended site, while controlled release can regulate exposure. These effects explain why delivery design is relevant to treatment outcomes, not merely administration convenience.