Name: Mixed Reality Assisted Radical Endoscopic Thyroidectomy (Video) | JoVE Journal
Uploaded: 2025-01-31T13:40:00.000+00:00
Duration: 8 min 6 s
Description: Learn mixed reality integration in radical endoscopic thyroidectomy for enhanced surgical safety and precision. This method provides real-time 3D holographic visualization to improve anatomical navigation and reduce operative risks.

ai_agent_IP

ai_agent

maintenance

instantTrialDurationMinutes

isBiopharma

enableNewMyJoveSectionDesign

educationFeatures

seoMetaApi

ai_copilot_institution_blacklist

ai_chat_institution_blacklist

freeAccessWindow

ssoRoleCapture

scheduledMaintenanceBanner

joveLabsFeatures

disable_autoplay_for_bots

extended_trial_duration

5 minutes

This study was funded by the National Natural Science Foundation Cultivation Program of The Third Affiliated Hospital of Sun Yat-sen University (2023GZRPYMS08) and funding by Science and Technology Projects in Guangzhou (SL2023A03J01216).&#160;The authors would also like to acknowledge the joint funding project of&#160;the Third Affiliated Hospital of Sun Yat-sen University and Chaozhou Central Hospital.

The protocol follows the guidelines of the human research ethics committee of Sun Yat-Sen University. No specific ethics approval is required since this treatment was performed in routine clinical care.
1. 3D reconstruction
<ol>
	<li>Import DICOM data from neck-enhanced CT scans into 3DSlicer10, utilizing a window width of 350 Hounsfield units (HU) and a window level of 40 HU.</li>
	<li>Segment and reconstruct the neck 3D model using a semi-automatic approach.
	<ol>
		<li>Segment and reconstruct the skin using the Threshold and Hollow functions. First, create a segmentation for CT values greater than -250 HU with the Threshold function. Then, utilize the Hollow function to remove the interior of this segmentation.</li>
		<li>Segment and reconstruct the thyroid, lesion, trachea, and esophagus using the Grow from seeds function based on either arterial or venous phase images. Manually delineate seeds within the target structures across cross-sectional, sagittal, and coronal images. Following this, automatically generate the target segmentation using the Grow from seeds function.</li>
		<li>Segment and reconstruct the bone using the Threshold function based on plain scanning images. Create this segmentation for CT values exceeding 200 HU.</li>
		<li>Segment and reconstruct arteries using the Local threshold function based on arterial phase images. Manually delineate seeds within the arteries in the coronal images. Subsequently, create a segmentation with a CT value range consistent with the seeds using the Local threshold function, and repeat the procedure to gradually expand the segmentation.</li>
		<li>Segment and reconstruct veins using the Local threshold function based on venous phase images. Use the specific operations identical to those described in the previous step.</li>
	</ol>
	</li>
	<li>Automatically reconstruct the neck 3D model using volume rendering.
	<ol>
		<li>Select either arterial phase images or venous phase images within the volume rendering module.</li>
		<li>Opt for an optimal automatic reconstruction protocol, typically the coronary enhanced CT reconstruction protocol, emphasizing visualizing the superior and inferior thyroid vessels.</li>
		<li>Minimize unnecessary reconstruction by precisely adjusting the region of interest.</li>
	</ol>
	</li>
</ol>
2. Constructing the neck virtual hologram
<ol>
	<li>Export the semi-automatically reconstructed neck 3D model from 3DSlicer as an OBJ file.</li>
	<li>Create a new project in Unity3D utilizing the Mixed Reality Toolkit (MRTK) and configure the necessary components.
	<ol>
		<li>Add a control border by utilizing the Box collider component.</li>
		<li>Implement a movable cursor using the Cursor Context Object Manipulator component.</li>
		<li>Add movement, scaling, and rotation functions through the Object manipulator, Near interaction Grabbable, and Min Max Scale Constraint components.</li>
		<li>Enable transparency control by utilizing the Slider Transparency Controller component.</li>
	</ol>
	</li>
	<li>Import the OBJ file into the project and associate the aforementioned components with the neck 3D model.</li>
	<li>Debug the neck virtual hologram on the MR head-mounted device (HMD) using the Holographic Remoting program, followed by packaging and exporting the project from Unity3D11.</li>
	<li>Install the neck virtual hologram onto the MR HMD using the Visual Studio program.</li>
</ol>
3. MR device manipulation
<ol>
	<li>Wear the MR HMD before surgery or have circulating nurses assist in wearing the HMD during surgery.</li>
	<li>Use MR HMD to manipulate the neck virtual holograms.
	<ol>
		<li>Control the movement, scaling, and rotation of the neck virtual hologram using a Grab gesture.</li>
		<li>Adjust the transparency of the neck virtual hologram by dragging the corresponding virtual slider.</li>
		<li>Align the neck virtual hologram with the patient&#39;s position, ensuring proper alignment of anatomical markers such as the mandible and clavicle.</li>
	</ol>
	</li>
	<li>Import clinical data such as neck CT images, ultrasonography and laboratory examination results into the MR HMD to access this information at any time during surgery.</li>
	<li>Control the HMD to capture MR images and videos through voice commands.</li>
	<li>Share the first-person perspective through the MR HMD via a Wi-Fi connection.</li>
</ol>
4. Preoperative stage
<ol>
	<li>Inclusion criteria
	<ol>
		<li>Include patients with papillary thyroid carcinoma (PTC) with a maximum diameter &#8804; 3 cm.</li>
		<li>Include patients who express a requirement for beauty.</li>
	</ol>
	</li>
	<li>Exclusion criteria
	<ol>
		<li>Exclude patients who are unable to tolerate surgery or general anesthesia.</li>
		<li>Exclude patients exhibiting extrathyroidal invasion or distant metastasis of PTC.</li>
		<li>Exclude patients with a history of thyroid surgery, ablation, or radioactive iodine treatment.</li>
		<li>Exclude patients with chest or clavicle deformities.</li>
		<li>Exclude patients with hypoparathyroidism or vocal cord dysfunction.</li>
	</ol>
	</li>
	<li>Auxiliary examination
	<ol>
		<li>Conduct neck-enhanced CT and ultrasonography to assess the PTC and its surrounding anatomy.</li>
		<li>Conduct chest radiography, electrocardiogram, complete blood count, liver and kidney function tests, and coagulation tests to exclude any absolute surgical contraindications.</li>
		<li>Conduct thyroid and parathyroid function tests, along with thyroglobulin levels.</li>
		<li>Conduct fiberoptic laryngoscopy to evaluate vocal cord function.</li>
	</ol>
	</li>
	<li>Preoperative preparation
	<ol>
		<li>Fast patients for 10 h and administer intravenous glucose saline or Ringer&#39;s solution.</li>
		<li>Administer midazolam, propofol, sufentanil, and atracurium intravenously to induce general anesthesia, followed by transoral tracheal intubation. Avoid using muscle relaxants during the maintenance phase of anesthesia.</li>
		<li>Perform urethral catheterization.</li>
		<li>Connect the intraoperative neuromonitoring (IONM) device.</li>
		<li>Position the patient in a split-leg configuration and extend their neck by tilting their head back. Position the endoscope system at the front of the patient&#39;s head.</li>
	</ol>
	</li>
</ol>
5. Surgical procedure (breast approach)
<ol>
	<li>Disinfect the surgical field, lay down the aseptic operating towels, and connect the endoscope, electrocoagulation hook, suction unit, and ultrasound knife.</li>
	<li>Identify the observation hole located 2 cm to the right of the midpoint of the line connecting the bilateral nipples. Inject expansion fluid subcutaneously and dissect using a stripping rod.</li>
	<li>Place a 10 mm Trocar and introduce carbon dioxide to establish an operating space with internal pressure maintained at less than 6 mmHg.</li>
	<li>Use the upper edge of both areolas as the operating channel. Dissect the subcutaneous cavities on both sides with two 5 mm or 10 mm Trocar needles under 30&#176; laparoscopic visualization. Insert the ultrasonic knife and scatheless forceps, and extend the subcutaneous space towards the front of the neck.</li>
	<li>Separate the cervical white line to free the thyroid gland. Suspend the ribbon muscles with sutures to extend the field of view.</li>
	<li>Inject carbon nanoparticles into the thyroid gland to stain it and the cervical lymph nodes.</li>
	<li>Disconnect the isthmus of the thyroid to expose the trachea and detach the suspensory ligament of the thyroid.</li>
	<li>Utilize the ultrasonic knife to coagulate the superior thyroid artery and vein, inferior thyroid artery, and middle thyroid vein. Secure the larger blood vessels with absorbable clamps.</li>
	<li>Perform auto-transplantation of PGs into the homolateral sternocleidomastoid muscle if the PG is removed or its blood supply is destroyed.</li>
	<li>Identify the RLN and superior laryngeal nerve using the IONM probe. Protect the nerves with wet gauze to prevent thermal injury.</li>
	<li>Carefully separate and excise the lesional thyroid gland, ensuring it is completely retrieved using a specimen bag.</li>
	<li>Perform homolateral lymphadenectomy in the cervical central region. If indicated, proceed with contralateral thyroidectomy and lymphadenectomy.</li>
	<li>Ensure all bleeding is thoroughly controlled, and rinse the surgical field with sterile distilled water. Insert a drainage tube in the operating channel and suture the incision layer by layer.</li>
</ol>
6. Postoperative management
<ol>
	<li>Provide electrocardiogram monitoring and oxygen therapy as patients return to the ward. Subsequently, administer treatments that include fluid replacement, intravenous calcium, pain relief, inhalation drug therapy, and phlegm clearance. If required, administer hemostatic drugs and initiate physical therapy.</li>
	<li>On the first postoperative day, discontinue electrocardiogram monitoring and oxygen therapy and remove the urinary catheter. Patients may resume a full diet and take daily oral doses of levothyroxine and calcium.</li>
	<li>On the second or third postoperative day, remove the drainage tube and prepare for patient discharge.</li>
	<li>Instruct the patient to visit the outpatient department for follow-up during the first week after surgery, as well as at 1 month, 3 months, 6 months, and 12 months postoperatively. Routinely review thyroid function and thyroglobulin levels, and perform neck ultrasonography.</li>
</ol>

<ol><li>Mu, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Mapping+global+epidemiology+of+thyroid+nodules+among+general+population%3A+A+systematic+review+and+meta-analysis%5BTitle%5D)+AND+%22Front+Oncol%22%5BJournal%5D)">Mapping global epidemiology of thyroid nodules among general population: A systematic review and meta-analysis.</a> Front Oncol. 12, 1029926(2022).</li>
<li>Bray, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Global+cancer+statistics+2022%3A+GLOBOCAN+estimates+of+incidence+and+mortality+worldwide+for+36+cancers+in+185+countries%5BTitle%5D)+AND+%22CA+Cancer+J+Clin%22%5BJournal%5D)">Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.</a> CA Cancer J Clin. 74 (3), 229-263 (2024).</li>
<li>Kitahara, C. M., Sosa, J. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+changing+incidence+of+thyroid+cancer%5BTitle%5D)+AND+%22Nat+Rev+Endocrinol%22%5BJournal%5D)">The changing incidence of thyroid cancer.</a> Nat Rev Endocrinol. 12 (11), 646-653 (2016).</li>
<li>Fassari, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Definition+of+learning+curve+for+thyroidectomy%3A+systematic+review+on+the+different+approaches%5BTitle%5D)+AND+%22Gland+Surg%22%5BJournal%5D)">Definition of learning curve for thyroidectomy: systematic review on the different approaches.</a> Gland Surg. 12 (7), 989-1006 (2023).</li>
<li>Shaha, A. R., Michael Tuttle, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Completion+thyroidectomy-indications+and+complications%5BTitle%5D)+AND+%22Eur+J+Surg+Oncol%22%5BJournal%5D)">Completion thyroidectomy-indications and complications.</a> Eur J Surg Oncol. 45 (7), 1129-1131 (2019).</li>
<li>Giordano, D., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Complications+of+central+neck+dissection+in+patients+with+papillary+thyroid+carcinoma%3A+results+of+a+study+on+1087+patients+and+review+of+the+literature%5BTitle%5D)+AND+%22Thyroid%22%5BJournal%5D)">Complications of central neck dissection in patients with papillary thyroid carcinoma: results of a study on 1087 patients and review of the literature.</a> Thyroid. 22 (9), 911-917 (2012).</li>
<li>Bian, D., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((The+application+of+extended+reality+technology-assisted+intraoperative+navigation+in+orthopedic+surgery%5BTitle%5D)+AND+%22Front+Surg%22%5BJournal%5D)">The application of extended reality technology-assisted intraoperative navigation in orthopedic surgery.</a> Front Surg. 11, 1336703(2024).</li>
<li>Doughty, M., Ghugre, N. R., Wright, G. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Augmenting+performance%3A+A+systematic+review+of+optical+see-through+head-mounted+displays+in+surgery%5BTitle%5D)+AND+%22J+Imaging%22%5BJournal%5D)">Augmenting performance: A systematic review of optical see-through head-mounted displays in surgery.</a> J Imaging. 8 (7), 203(2022).</li>
<li>Hart, S. G., Staveland, L. E. Development of NASA-TLX (Task Load Index): results of empirical and theoretical research. <a target="_blank" href="http://scholar.google.com/scholar?hl=en&safe=off&q=author%3aHart%2C+SG+%22Adv+Psychol%22">Adv Psychol</a>. 52, 139e183(1988).</li>
<li>Fedorov, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((3D+Slicer+as+an+image+computing+platform+for+the+Quantitative+Imaging+Network%5BTitle%5D)+AND+%22Magn+Reson+Imaging%22%5BJournal%5D)">3D Slicer as an image computing platform for the Quantitative Imaging Network.</a> Magn Reson Imaging. 30 (9), 1323-1341 (2012).</li>
<li>Palumbo, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Microsoft+HoloLens+2+in+medical+and+healthcare+context%3A+State+of+the+art+and+future+prospects%5BTitle%5D)+AND+%22Sensors+%28Basel%29%22%5BJournal%5D)">Microsoft HoloLens 2 in medical and healthcare context: State of the art and future prospects.</a> Sensors (Basel). 22 (20), 7709(2022).</li>
<li>Khan, U., Yasin, A., Abid, M., Shafi, I., Khan, S. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((A+methodological+review+of+3D+reconstruction+techniques+in+tomographic+imaging%5BTitle%5D)+AND+%22J+Med+Syst%22%5BJournal%5D)">A methodological review of 3D reconstruction techniques in tomographic imaging.</a> J Med Syst. 42 (10), 190(2018).</li>
<li>Liu, X., Sun, J., Zheng, M., Cui, X. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Application+of+mixed+reality+using+optical+see-through+head-mounted+displays+in+transforaminal+percutaneous+endoscopic+lumbar+discectomy%5BTitle%5D)+AND+%22Biomed+Res+Int%22%5BJournal%5D)">Application of mixed reality using optical see-through head-mounted displays in transforaminal percutaneous endoscopic lumbar discectomy.</a> Biomed Res Int. 2021, 9717184(2021).</li>
<li>Wierzbicki, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((3D+mixed-reality+visualization+of+medical+imaging+data+as+a+supporting+tool+for+innovative%2C+minimally+invasive+surgery+for+gastrointestinal+tumors+and+systemic+treatment+as+a+new+path+in+personalized+treatment+of+advanced+cancer+diseases%5BTitle%5D)+AND+%22J+Cancer+Res+Clin+Oncol%22%5BJournal%5D)">3D mixed-reality visualization of medical imaging data as a supporting tool for innovative, minimally invasive surgery for gastrointestinal tumors and systemic treatment as a new path in personalized treatment of advanced cancer diseases.</a> J Cancer Res Clin Oncol. 148 (1), 237-243 (2022).</li>
<li>Kitagawa, M., Sugimoto, M., Haruta, H., Umezawa, A., Kurokawa, Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Intraoperative+holography+navigation+using+a+mixed-reality+wearable+computer+during+laparoscopic+cholecystectomy%5BTitle%5D)+AND+%22Surgery%22%5BJournal%5D)">Intraoperative holography navigation using a mixed-reality wearable computer during laparoscopic cholecystectomy.</a> Surgery. 171 (4), 1006-1013 (2022).</li>
<li>Zhou, Z., Yang, Z., Jiang, S., Zhuo, J., Zhu, T., Ma, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Augmented+reality+surgical+navigation+system+based+on+the+spatial+drift+compensation+method+for+glioma+resection+surgery%5BTitle%5D)+AND+%22Med+Phys%22%5BJournal%5D)">Augmented reality surgical navigation system based on the spatial drift compensation method for glioma resection surgery.</a> Med Phys. 49 (6), 3963-3979 (2022).</li>
<li>Wang, L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Application+of+a+three-dimensional+visualization+model+in+intraoperative+guidance+of+percutaneous+nephrolithotomy%5BTitle%5D)+AND+%22Int+J+Urol%22%5BJournal%5D)">Application of a three-dimensional visualization model in intraoperative guidance of percutaneous nephrolithotomy.</a> Int J Urol. 29 (8), 838-844 (2022).</li>
<li>Van Gestel, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Neuro-oncological+augmented+reality+planning+for+intracranial+tumor+resection%5BTitle%5D)+AND+%22Front+Neurol%22%5BJournal%5D)">Neuro-oncological augmented reality planning for intracranial tumor resection.</a> Front Neurol. 14, 1104571(2023).</li>
<li>Costa, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Head-mounted+augmented+reality+in+the+planning+of+cerebrovascular+neurosurgical+procedures%3A+A+single-center+initial+experience%5BTitle%5D)+AND+%22World+Neurosurg%22%5BJournal%5D)">Head-mounted augmented reality in the planning of cerebrovascular neurosurgical procedures: A single-center initial experience.</a> World Neurosurg. 171, e693-e706 (2023).</li>
<li>Wong, K. C., Sun, E. Y., Wong, I. O. L., Kumta, S. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Mixed+reality+improves+3D+visualization+and+spatial+awareness+of+bone+tumors+for+surgical+planning+in+orthopaedic+oncology%3A+A+proof+of+concept+study%5BTitle%5D)+AND+%22Orthop+Res+Rev%22%5BJournal%5D)">Mixed reality improves 3D visualization and spatial awareness of bone tumors for surgical planning in orthopaedic oncology: A proof of concept study.</a> Orthop Res Rev. 15, 139-149 (2023).</li>
<li>Saadya, A., Chegini, S., Morley, S., McGurk, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Augmented+reality+presentation+of+the+extracranial+facial+nerve%3A+an+innovation+in+parotid+surgery%5BTitle%5D)+AND+%22Br+J+Oral+Maxillofac+Surg%22%5BJournal%5D)">Augmented reality presentation of the extracranial facial nerve: an innovation in parotid surgery.</a> Br J Oral Maxillofac Surg. 61 (6), 428-436 (2023).</li>
<li>Suter, D., Hodel, S., Liebmann, F., Fürnstahl, P., Farshad, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Factors+affecting+augmented+reality+head-mounted+device+performance+in+real+OR%5BTitle%5D)+AND+%22Eur+Spine+J%22%5BJournal%5D)">Factors affecting augmented reality head-mounted device performance in real OR.</a> Eur Spine J. 32 (10), 3425-3433 (2023).</li>
<li>Morley, C. T., Arreola, D. M., Qian, L., Lynn, A. L., Veigulis, Z. P., Osborne, T. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Mixed+reality+surgical+navigation+system%3B+positional+accuracy+based+on+Food+and+Drug+Administration+standard%5BTitle%5D)+AND+%22Surg+Innov%22%5BJournal%5D)">Mixed reality surgical navigation system; positional accuracy based on Food and Drug Administration standard.</a> Surg Innov. 31 (1), 48-57 (2024).</li>
<li>Razavi, C. R., Tanavde, V., Shaear, M., Richmon, J. D., Russell, J. O. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Simulations+and+simulators+in+head+and+neck+endocrine+surgery%5BTitle%5D)+AND+%22Ann+Thyroid%22%5BJournal%5D)">Simulations and simulators in head and neck endocrine surgery.</a> Ann Thyroid. 5, 3(2020).</li>
<li>Wang, B., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Development+of+artificial+intelligence+for+parathyroid+recognition+during+endoscopic+thyroid+surgery%5BTitle%5D)+AND+%22Laryngoscope%22%5BJournal%5D)">Development of artificial intelligence for parathyroid recognition during endoscopic thyroid surgery.</a> Laryngoscope. 132 (12), 2516-2523 (2022).</li>
<li>Park, B. J., Shah, S., Konik, D., Lim, J. Y., Huber, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((An+ergonomic+holographic+procedural+monitor+for+thyroid+radiofrequency+ablation+using+a+mixed-reality+headset%5BTitle%5D)+AND+%22J+Vasc+Interv+Radiol%22%5BJournal%5D)">An ergonomic holographic procedural monitor for thyroid radiofrequency ablation using a mixed-reality headset.</a> J Vasc Interv Radiol. 34 (2), 307-310 (2023).</li>
</ol>

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

MR is a cutting-edge AI technology based on various algorithmic models and sensing devices. The purpose of this protocol is to utilize MR to assist in radical ET. Moreover, the key procedure is the construction of the neck 3D model and virtual hologram. Subjective scales indicate positive results, demonstrating that MR is benefitial for surgeons in performing radical ET with ease. Additionally, MR exhibits potential advantages in preventing complications associated with ET. However, the small sample size limits the signi...

Over the past decade, the global incidence of thyroid nodules has risen to 29.29%, reflecting an increase of 7.76% compared to the previous decade. This trend positions thyroid nodules as one of the most prevalent diseases1. Concurrently, the incidence of thyroid cancer has reached 20/100,000, ranking it seventh among all cancers and third among females. Radical surgery remains the preferred treatment approach2.
Thyroidectomy can be categorized into open, endoscopic, and robotic surgeries. Endoscopic thyroidectomy (ET) is a form of cosmetic surgery that employs the length of endoscopic instruments to create subcutaneous tunnels through incisions made in the areola, axilla, oral cavity, and other concealed areas, thereby facilitating a scarless appearance in the neck. This approach is particularly appealing to women, who constitute the majority of thyroid cancer patients3. However, ET still requires further optimization from a surgical perspective. Firstly, ET is challenged by limited surgical space and a lack of tactile feedback, which complicates the operation and contributes to a prolonged learning curve4. Secondly, the thyroid possesses special physiological functions and complex local anatomy, making ET susceptible to serious complications, such as hypoparathyroidism and recurrent laryngeal nerve (RLN) injury5. Additionally, thyroid cancer often presents with occult lymphatic metastasis, and incomplete cervical lymph node dissection may further elevate the risk of postoperative lymphatic recurrence6, leading to the necessity for secondary or even multiple surgeries in some patients.
Artificial intelligence (AI) is an emerging field that seeks to simulate and enhance human intelligence through computer algorithms. Extended reality (XR) is a category of AI techniques that can deliver highly realistic audiovisual information in real-time, particularly suited for surgical applications7. Mixed reality (MR), a subset of XR, integrates virtual holograms with real-world entities, enabling users to interact seamlessly between reality and virtual environments8. Three-dimensional (3D) reconstruction is a computer graphics technique that transforms two-dimensional (2D) images composed of pixels into 3D models made up of voxels. The presentation of 3D models is crucial, and the primary application of MR in surgery involves displaying 3D models constructed from tomographic images, such as computed tomography (CT) and magnetic resonance imaging (MRI).
In this study, MR was utilized to assist in radical ETwith the aim of enhancing its efficacy and safety while reducing surgical complexity. Patients diagnosed with thyroid cancer who met specified inclusion and exclusion criteria were randomly assigned to either the experimental group or the control group. Those in the experimental group underwent MR-assisted radical ET. A comparative analysis of the surgical outcomes between the two groups was conducted. Furthermore, the National Aeronautics and Space Administration Task Load Index Scale (NASA-TLX) and the Likert Subjective Rating Scale were employed to assess the impact of MR-assisted ET on the surgeons. NASA-TLX is recognized as the gold standard for subjective workload assessment and comprises six dimensions: mental demand (MD), physical demand (PD), temporal demand (TF), own performance (OP), effort (EF), and frustration (FR)9. Each dimension is rated independently on a scale of 0 to 100. The Likert Subjective Rating Scale includes a series of questions with five response levels ranging from very satisfied (5 points) to very dissatisfied (1 point), with the intermediate levels being satisfied (4 points), acceptable (3 points), and dissatisfied (2 points).

<table><tbody><tr><td>3DSlicer</td><td>Slicer</td><td></td><td>https://www.slicer.org/</td></tr><tr><td>HoloLens2</td><td>Microsoft</td><td></td><td>a type of mixed reality helmet mounted display&lt;br/&gt; https://www.microsoft.com/en-us/hololens/hardware#document-experiences</td></tr></tbody></table>

mixed reality assisted radical endoscopic thyroidectomy

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Radical endoscopic thyroidectomy (ET) offers superior cosmetic outcomes and enhanced visibility of the surgical field compared to open surgery. However, the thyroid&#39;s unique physiological functions and intricate surrounding anatomy may result in various surgical complications. Mixed reality (MR), a real-time holographic visualization technology, enables the creation of highly realistic 3D models in the real world and facilitates multiple human-computer interactions. MR can be utilized for both preoperative evaluation and intraoperative navigation. First, semi-automatic 3D reconstruction of the neck from enhanced computed tomography images is performed using 3Dslicer. Next, the 3D model is imported into Unity3D to create a virtual hologram that can be displayed on an MR helmet-mounted display (HMD). During surgery, surgeons can wear the MR HMD to locate lesions and surrounding anatomy through the virtual hologram. In this study, patients requiring radical ET were randomly assigned to either the experimental group or the control group. Surgeons performed MR-assisted radical ET in the experimental group. A comparative analysis of surgical outcomes and the results of scales was conducted.&#160;This study successfully developed the neck 3D model and the virtual hologram. According to the NASA Task Load Index Scale, the experimental group exhibited significantly higher scores in &#39;Own Performance&#39; and lower scores in &#39;Effort&#39; compared to the control group (p = 0.002). Additionally, on the Likert Subjective Evaluation Scale, the mean scores for all questions exceeded 3. Although the incidence of surgical complications was lower in the experimental group than in the control group, the differences in surgical outcomes were not statistically significant.MR is beneficial for enhancing performance and alleviating the burden of surgeons during the perioperative period. Furthermore, MR has demonstrated the potential to enhance the safety of ET. Therefore, it is essential to further investigate the surgical applications of MR.

This study successfully constructed the neck 3D model of patients with PTC (Figure 1) and performed 14 cases of MR-assisted radical ET (Figure 2).
A total of 32 ETs were performed by a senior surgeon, who completed the NASA-TLX and the Likert Subjective Rating Scale (Table 1 and Table 2) following the surgeries. In the NASA-TLX, the experimental group exhibited a significantly higher OP score and lowe...

Radical endoscopic thyroidectomy is associated with various surgical complications. This study utilizes mixed reality techniques to assist surgeons in performing radical endoscopic thyroidectomy, aiming to enhance its safety and lower the surgical threshold.

Radical endoscopic thyroidectomy (ET) offers superior cosmetic outcomes and enhanced visibility of the surgical field compared to open surgery. However, ...

mixed-reality-assisted-radical-endoscopic-thyroidectomy

Research

JoVE Journal

Medicine

The robotic technique shown herein aims at faithfully reproducing the open procedure for radical treatment of cancer of the body-tail of the pancreas. The protocol also demonstrates the ability to master involvement of major peripancreatic vessels without conversion to open surgery.

Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction

Here, we present a protocol to describe the methodology for the transoral endoscopic thyroidectomy vestibular approach in detail.

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

This protocol presents the procedure for conducting thyroidectomy using the gasless endoscopic thyroidectomy trans-axillary approach (GETTA).

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

The transoral robotic total thyroidectomy and bilateral central regional lymph node dissection using three ports without axillary incision are feasible and safe for early-stage papillary thyroid carcinoma. Here we present the operative techniques of this operation.

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Here, we present a protocol for retrosternal thyroid goiter resection using a thoracoscopic-assisted transcervical approach.

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

The aim of this article is to present a method for identifying and protecting the recurrent laryngeal nerve during robotic thyroidectomy through the oral vestibular approach in the absence of the laryngeal nerve monitor.

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy

Endoscopic en bloc resection for thyroid carcinoma presents significant technical challenges, with current literature lacking comprehensive methodological descriptions. A systematic development and description of the "Sun's Seven-Step Technique" for endoscopic en-bloc thyroidectomy via the chest-breast approach was presented, demonstrating its superior operative efficiency, safety, and clinical feasibility.

"Sun's Seven-Step Technique" for Endoscopic En-Bloc Resection of Thyroid Cancer via the Chest-Breast Approach

This protocol presents a novel contralateral axillo-bilateral-breast approach for endoscopic thyroidectomy that optimizes surgical positioning and operative space while achieving excellent cosmetic outcomes.

A Novel Contralateral Axillo-Bilateral-Breast Approach for Endoscopic Thyroid Surgery

Accuracy is a major demand in dental medicine. To verify accuracy, reference scanners are needed. This article presents a new reference scanner with an adjusted scanning method to acquire a broad variety of dental morphologies with high trueness and precision.

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision

In vitro maturation (IVM) before gynecological operation (OP-IVM) combines IVM following oocyte retrieval with routine gynecological surgery and serves as an extension of conventional IVM applications for fertility preservation.

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Learn mixed reality integration in radical endoscopic thyroidectomy for enhanced surgical safety and precision. This method provides real-time 3D holographic visualization to improve anatomical navigation and reduce operative risks.

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Explore More Videos