Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Betsaida J. Ortiz-S&#225;nchez; Imelda Ju&#225;rez Avelar; Miriam Rodriguez-Sosa

doi:10.3791/67848

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

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07:14 min

May 30, 2025

DOI: 10.3791/67848-v

Betsaida J. Ortiz-Sánchez^1,2, Imelda Juárez Avelar^2,3, Miriam Rodriguez-Sosa²

¹Undergraduate Program of Dental Surgeon, Facultad de Estudios Superiores Iztacala (FES-Iztacala),Universidad Nacional Autónoma de Mexico (UNAM), ²Innate Immunity Laboratory, Biomedicine Research Unit (UBIMED), FES-Iztacala,UNAM, ³Doctoral Program in Biological Sciences,UNAM

This study describes a modified 6-0 nylon ligation method for inducing periodontitis in mice, which is highly reproducible and represents an alternative for researchers to study periodontal disease from its development to its pathological consequences.

The scope of our research is to study the cellular and molecular factors that favor periodontitis for which we use a murine model of ligature-induced periodontitis.

Recent research has established the importance of inflammation. Dysbiosis and systemic diseases are determining factors in the development of periodontitis.

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