Name: Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis (Video) | JoVE Journal
Uploaded: 2025-05-16T13:50:00.000+00:00
Duration: 6 min 19 s
Description: Learn Chinese herbal retention enema for ulcerative colitis treatment using clinical trial methods. This approach demonstrates improved symptom scores and quality of life compared to conventional oral mesalazine therapy.

ai_agent_IP

ai_agent

maintenance

instantTrialDurationMinutes

isBiopharma

enableNewMyJoveSectionDesign

educationFeatures

seoMetaApi

ai_copilot_institution_blacklist

ai_chat_institution_blacklist

freeAccessWindow

ssoRoleCapture

scheduledMaintenanceBanner

joveLabsFeatures

disable_autoplay_for_bots

extended_trial_duration

5 minutes

This work was supported by the Sichuan Provincial Administration of Traditional Chinese Medicine Scientific and Technological Research Special Project (2024zd004) and the Sichuan Provincial Key Research and Development Project (2024YFFK0171).

The protocol has been approved by the Ethics Committee of the Hospital of Chengdu University of Traditional Chinese Medicine (Ethics No.: 2024KL-182-01). The operational procedures comply with the clinical guidelines of the Hospital of Chengdu University of Traditional Chinese Medicine. Informed consent was obtained from all patients for participation in the study.
1. Patient assessment
<ol>
	<li>Confirm that the diagnosis meets the criteria for UC23. Verify the patient is willing to accept Chinese herbal retention enema treatment and has signed an informed consent form.</li>
	<li>Exclude patients with serious complications, such as lower gastrointestinal bleeding, obstruction, perforation, severe heart failure, liver or kidney dysfunction, hematological disorders, malignant tumors, mental disorders, or a history of allergy to Chinese herbs. Also, exclude patients with perianal skin lesions, severe hemorrhoids, or those who have undergone anal, rectal, or colonic surgery within the past 3 months. Exclude pregnant or lactating females.</li>
</ol>
2. Patient preparation
<ol>
	<li>Instruct the patient to empty their bowels and bladder 30 min before the enema procedure. Explain the procedure steps, safety precautions, and therapeutic benefits in detail to alleviate anxiety and ensure patient cooperation.</li>
	<li>Perform a routine cleansing enema prior to the herbal retention enema if fecal residue is present. Prepare a warm saline solution (approximately 500-1000 mL) at body temperature (37 &#176;C-40 &#176;C). Close the enema bag tube clamp to prevent leakage and fill the enema bag with warm saline.</li>
	<li>Position the patient in left lateral decubitus with knees flexed. Loosen the clothing and pull the pants down to mid-thigh, fully exposing the anal area. Lubricate the rectal tube with paraffin oil and gently insert it into the anus to a depth of 7-10 cm, guided by the graduated centimeter markings on the proximal segment of the tube.</li>
	<li>Hang the enema bag on the infusion stand, ensuring that the liquid level is approximately 40 cm above the anus. Open the clamp of the rectal tube and allow the warm saline solution to flow slowly into the rectum. Once the infusion is complete, close the clamp, carefully remove the rectal tube, and clean the anus with wet tissue. Instruct the patient to lie flat and retain the saline for 5-10 minutes to facilitate adequate bowel distension and cleansing.</li>
	<li>After the retention period, provide the patient with a bedpan to evacuate the saline and fecal. Assess the clarity of the expelled solution to determine whether further enemas are required. Repeat the enema procedure 2-3 times, if necessary, until the discharged saline is clear and free of fecal residue. If the patient develops pallor, cold sweat, severe abdominal pain, or panic, stop immediately and notify the physician.</li>
</ol>
3. Material preparation
<ol>
	<li>Preparation of herbal decoction
	<ol>
		<li>Weigh the following herbs (Figure 1): Sanguisorba officinalis L. (Sanguisorbae radix) 20 g, Sophora japonica L. (Sophorae flos) 10 g, Portulaca oleracea L. (Portulacae herba) 10 g, Baphicacanthus cusia (Nees) Bremek. (Indigo naturalis) 30 g, Paeonia lactiflora Pall. (Radix paeoniae rubra) 10 g.</li>
		<li>Place the herbs in a clay pot. Add enough cold water to submerge up to 2-3 cm. Soak the herbs for 30 min.</li>
		<li>Bring the water to a boil, then simmer for 30 min. Filter through two layers of medical gauze and retain the decoction.</li>
		<li>Add cold water again to submerge the herbs by 2-3 cm. Bring it to a boil once more and simmer for another 30 min. Filter through two layers of medical gauze and retain the decoction.</li>
		<li>Combine the two decoctions and allow it to cool to a suitable temperature (approximately 39 &#176;C-41 &#176;C) for use.</li>
	</ol>
	</li>
	<li>Preparation of other materials
	<ol>
		<li>Prepare an asepsis enemator for a single-use kit (including a single-use sterile enema device, disposable gloves, a disposable treatment tray, a medical treatment towel, and paraffin oil), a water thermometer, gauze, a cushion, a bedpan, and a privacy screen (Figure 2 and Table of Materials).</li>
	</ol>
	</li>
</ol>
4. Treatment procedure
<ol>
	<li>Administer conventional treatment to the control group: prescribe oral mesalazine enteric-coated tablets (4 g/day), combined with a personalized herbal decoction. Provide the enema group with additional daily Chinese herbal retention enemas.</li>
	<li>Confirm the patient&#39;s information (name, age, hospitalization number). Ensure the patient has emptied their bladder and bowel. Confirm that the patient has signed the informed consent form. Re-evaluate the patient&#39;s condition and assess the patient for any discomfort or adverse symptoms that may contraindicate the procedure. Check the expiration dates and integrity of all equipment.</li>
	<li>Close the doors and windows and adjust the room temperature to a comfortable level (approximately 22 &#176;C-28 &#176;C). Use a privacy screen to protect the patient&#39;s privacy.</li>
	<li>Wash hands, don gloves and a mask. Inspect the perianal area for lesions or contraindications.
	<ol>
		<li>Assess the skin condition: Inspect for redness, swelling, irritation, warmth, tenderness, or discharge.</li>
		<li>Examine for hemorrhoids: Palpate and visually inspect swelling, prolapse, or bleeding.</li>
		<li>Check for fissures or ulcers: Inspect for cracks, tears, or open sores around the anus.</li>
		<li>Examine for abscesses or infections: Palpate for lumps, swelling, redness, pus, or fluctuance.</li>
		<li>Ensure perianal hygiene: Clean the area thoroughly to remove fecal residue or debris.</li>
		<li>Identify contraindications: Report any concerning findings (e.g., recent surgery or infections) to the physician immediately.</li>
	</ol>
	</li>
	<li>Position the patient in left lateral decubitus with knees flexed. Loosen the clothing and pull the pants down to mid-thigh, fully exposing the anal area. Place a medical drape under the buttocks and elevate the hips by 10 cm using a cushion (see Figure 3).
	<ol>
		<li>Adjust the patient&#39;s position based on the lesion location: for rectal and sigmoid colon lesions, use the left lateral position; for ileocecal lesions, use the right lateral position.</li>
	</ol>
	</li>
	<li>Measure the herbal decoction temperature (39 &#176;C-41 &#176;C) using a water thermometer. Close the enema bag tube clamp to prevent leakage. Fill the disposable enema bag with &#8804; 200 mL of the decoction and hang it, ensuring the liquid level is no more than 30 cm from the anus.</li>
	<li>Lubricate the rectal tube tip with paraffin oil. Instruct the patient to perform deep oral breathing. Gently insert the tube 15-25 cm into the rectum.
	<ol>
		<li>Adjust the insertion depth based on the lesion location: for lesions in the rectum and sigmoid colon, insert the tube 15 to 20 cm; for lesions in the sigmoid or descending colon, insert 18 to 25 cm.</li>
	</ol>
	</li>
	<li>Open the enema bag tube clamp and slowly drip the herbal decoction, adjusting the infusion rate based on the patient&#39;s condition and tolerance. Maintain a total infusion time of 15-20 min. Continuously observe the patient and inquire about their tolerance. Adjust the infusion rate or discontinue the procedure if discomfort or the urge to defecate arises.
	<ol>
		<li>Stop the enema immediately if the patient shows signs of rapid pulse, pale complexion, cold sweats, severe abdominal pain, or palpitations. Notify the physician immediately.</li>
	</ol>
	</li>
	<li>Clamp the tube upon completion. Remove the tube slowly while asking the patient to contract anal sphincters. Cleanse the perianal area with gauze.</li>
	<li>Instruct the patient to remain in the supine position with hips elevated for 60 min. Provide a bedpan for controlled evacuation after the retention period.
	<ol>
		<li>For patients with poor retention (&#60; 30 min), add 2-3 mL of 1% lidocaine to the herbal decoction after physician approval.</li>
	</ol>
	</li>
	<li>Dispose of biohazardous waste in designated containers. Disinfect reusable equipment according to the Technical Specification for Disinfection in Healthcare Facilities24. Document the procedure details and the patient&#39;s response.</li>
</ol>
5. Postoperative care
<ol>
	<li>Open the windows to ensure proper ventilation. Replace the bed linens with clean sheets.</li>
	<li>Check for signs of abdominal distension, diarrhea, constipation, or other symptoms. Instruct the patient to avoid straining during bowel movements. Guide the patient to monitor and record daily stool characteristics, including frequency, color, odor, and consistency. Collect stool samples for further examination if abnormalities are observed.</li>
	<li>Advise the patient to rest and follow a light, easily digestible diet. Prohibit the consumption of hard, cold, raw, high-fiber, spicy, fried foods, and dairy products.</li>
	<li>Monitor the patient&#39;s vital signs (temperature, blood pressure, pulse, heart rate, and respiration rate) at 15 min intervals for the first hour after the procedure. Thereafter, assess the vital signs hourly for the next 4 h. Document any changes in symptoms promptly.</li>
</ol>
6. Drug efficacy evaluation
<ol>
	<li>Primary efficacy indicators
	<ol>
		<li>Assess UC symptoms using the individual symptom scores recommended by the Experts&#39; consensus on traditional Chinese medicine diagnosis and treatment of ulcerative colitis (2023)25 Score the following symptoms: 
		Diarrhea: 0 (none), 3 (&#60;4 times/day), 6 (4-6 times/day), 9 (&#62;6 times/day) 
		Mucopurulent Bloody Stools: 0 (none), 3 (small amounts of pus/blood), 6 (predominant pus/blood), 9 (entire stool composed of pus/fresh blood) 
		Abdominal Pain: 0 (none), 3 (mild/intermittent), 6 (moderate/recurrent), 9 (severe/cramping) 
		&#8203;Tenesmus: 0 (absent), 1 (present)</li>
		<li>Perform a baseline assessment upon admission. Administer the Chinese herbal retention enema daily for 14 consecutive days. Conduct the final efficacy evaluation 24 hours after the last enema. Compare post-treatment scores with baseline scores.</li>
	</ol>
	</li>
	<li>Secondary efficacy indicators
	<ol>
		<li>Assess quality of life using the Inflammatory Bowel Disease Questionnaire (IBD-Q)26. Evaluate the patient&#39;s social function, emotional status, systemic symptoms, and bowel-related symptoms. Higher scores indicate improved quality of life.</li>
		<li>Perform a baseline assessment upon admission and a follow-up evaluation 14 days after treatment completion.</li>
	</ol>
	</li>
</ol>

The authors have nothing to disclose.

UC is a chronic inflammatory disease primarily affecting the colorectal mucosa. Research has shown that rectal formulations of 5-aminosalicylic acid and corticosteroids can directly target the lesions, effectively reducing systemic reactions and demonstrating higher efficacy and safety compared to oral treatments12,27. However, these medications are still associated with unavoidable side effects, which has prompted increasing attention to the application of TCM a...

Ulcerative colitis (UC) is a chronic, nonspecific inflammatory bowel disease primarily affecting the colon and rectum, characterized by persistent or recurrent diarrhea, mucopurulent bloody stools, abdominal pain, tenesmus, and varying degrees of extraintestinal symptoms1. As a growing global health concern, UC exhibits a steadily increasing annual incidence, afflicting approximately 5 million patients worldwide in 2023, thereby imposing substantial burdens on healthcare systems and societies2,3. Despite advances in pharmacological interventions, current therapeutic strategies remain nonspecific and suboptimal. Mainstay treatments, including 5-aminosalicylic acid derivatives, glucocorticoids, immunomodulators, and biologics, are frequently associated with severe adverse effects. For example, mesalazine often causes pancreatitis, cardiotoxicity, and hepatotoxicity4, while corticosteroids commonly lead to weight gain, osteoporosis, and gastrointestinal bleeding5. Moreover, these medications tend to induce drug resistance and demonstrate limited efficacy in preventing disease recurrence6. Moreover, the high cost of some drugs places considerable economic strain on patients&#39; families7. Thus, there is an urgent need to develop safer and more cost-effective therapeutic alternatives.
Traditional Chinese Medicine (TCM) possesses a unique theoretical system, with medicinal substances primarily derived from natural sources such as plants, animals, and minerals, offering potential multi-target therapeutic effects, relatively favorable safety profiles, and economic accessibility8. With a documented history spanning thousands of years in the management of UC, TCM has garnered increasing validation for its ability to alleviate symptoms, reduce recurrence, and minimize adverse reactions9,10,11. Given the specific anatomical location of UC, local administration through the colorectal route is often more beneficial than oral administration12,13. Historical records indicate that as early as 200 AD, Chinese herbal retention enemas were employed in clinical practice14. This method involves the rectal administration of herbal decoction, which is retained for a designated period to ensure optimal contact with and absorption by the colonic mucosa15. In recent years, the Chinese herbal retention enema technique has gained international recognition and has been applied to various conditions, including acute pancreatitis16, chronic kidney disease17, and gynecological disorders18. Its application is particularly notable in colonic diseases19,20. Compared with oral drug administration, Chinese herbal retention enema delivers active compounds directly to the site of pathology, bypassing first-pass hepatic metabolism and minimizing degradation by digestive enzymes. This enhances the bioavailability of active components while reducing gastrointestinal irritation and systemic toxicity21. Notably, the rich vascularization and thin-walled venous structure of the rectal mucosa facilitate rapid drug absorption, promoting the resolution of inflammation and the repair of tight junctions within the intestinal mucosa, thereby improving overall mucosal integrity22. Although Western medicine has also adopted local administration methods, such as rectal delivery of 5-aminosalicylic acid and corticosteroids, to minimize systemic side effects, comparative evidence indicates that Chinese herbal retention enemas demonstrate superior therapeutic efficacy alongside a more favorable safety profile21.
Despite these advantages, the clinical application of Chinese herbal retention enemas remains limited due to the absence of standardized protocols and insufficient familiarity among healthcare professionals. Therefore, this paper systematically presents a standardized protocol for administering Chinese herbal retention enemas in the treatment of UC. The overall aim is to provide a detailed description of the procedure, including key steps and precautions, to ensure its clinical feasibility, reproducibility, and broad applicability in clinical practice.

<table><tbody><tr><td>Asepsis Enemator for Single Use</td><td>Shandong Weigao Group Medical Polymer Products Co., Ltd</td><td>20240511</td><td>Including a single-use sterile enema device, disposable gloves, a disposable treatment tray, medical treatment towel, and paraffin oil</td></tr><tr><td>Dedpan</td><td>Sichuan Hualikang Medical Technology Co.</td><td>YGBX2401</td><td>Covered Type B</td></tr><tr><td>Gauze</td><td>Shandong Ang Yang Medical Technology Co.</td><td>2023110201</td><td>8 cm &amp;times; 8 cm - 8p, 2 pcs/bag</td></tr><tr><td>Indigo Naturalis</td><td>Sichuan Province Traditional Chinese Medicine Decoction Pieces Co., Ltd</td><td>240219</td><td>Origin: Fujian Province</td></tr><tr><td>Portulacae Herba</td><td>Sichuan Guoqiang Traditional Chinese Medicine Pieces Co., Ltd</td><td>2406156</td><td>Origin: Sichuan Province</td></tr><tr><td>Privacy Screen</td><td>Henan Xingda Medical Equipment Manufacturing Co., Ltd</td><td>A002</td><td>2 &amp;times; 1.8 m</td></tr><tr><td>Radix Paeoniae Rubra</td><td>Sichuan New Lotus Traditional Chinese Medicine Pieces Co., Ltd</td><td>2410132</td><td>Origin: Sichuan Province</td></tr><tr><td>Radix Sanguisorbae</td><td>Sichuan Guoqiang Traditional Chinese Medicine Pieces Co., Ltd</td><td>2408127</td><td>Origin: Gansu Province</td></tr><tr><td>Sophora Japonica</td><td>Sichuan Guoqiang Traditional Chinese Medicine Pieces Co., Ltd</td><td>231201</td><td>Origin: Shanxi Province</td></tr><tr><td>Water Thermometer</td><td>Hongchang Instrument Factory in Wuqiang County</td><td>WNG-01</td><td>30cm</td></tr></tbody></table>

chinese herbal retention enema for the treatment of ulcerative colitis

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Ulcerative colitis (UC) is a globally prevalent and refractory disease that imposes a substantial socioeconomic burden, with no universally effective treatment currently available. Traditional Chinese medicine (TCM) demonstrated promising therapeutic potential in UC management, particularly through the application of Chinese herbal retention enema, which is gaining increasing international recognition. This method involves the rectal administration of an herbal decoction, which is retained for a designated period to ensure optimal contact with and absorption by the colonic mucosa. Compared to oral administration, this method offers distinct pharmacological advantages by bypassing hepatic first-pass metabolism, enhancing therapeutic effects, and minimizing systemic side effects. This study presents a comprehensive protocol for Chinese herbal retention enema in UC treatment, including patient assessment, material preparation, position selection, enema administration, postoperative care, and emergency management. A clinical trial was conducted with 22 UC patients divided into control and enema groups. Therapeutic outcomes were evaluated using individual symptom scores and the Inflammatory Bowel Disease Questionnaire (IBD-Q). The results indicated that Chinese herbal retention enema had a more significant advantage in improving clinical symptoms (mucopurulent bloody stools and abdominal pain) and quality of life (intestinal symptoms, systemic symptoms, and social functioning) compared to the control group (p &#60; 0.05). These findings suggest that Chinese herbal retention enema represents an effective, well-tolerated, and patient-adaptable therapeutic approach, offering a promising complementary treatment option for UC management.

This study included 22 UC patients from the Department of Gastroenterology at the Hospital of Chengdu University of Traditional Chinese Medicine. The control group received conventional treatment (oral mesalazine enteric-coated tablets combined with a personalized herbal decoction), while the enema group received additional daily Chinese herbal retention enemas.
The outcome measures of this study were the individual symptom scores and the IBD-Q scores. The individual symptom scores are shown i...

This article demonstrates a Chinese herbal retention enema method for treating ulcerative colitis, which can effectively improve patients' clinical symptoms and quality of life.

Ulcerative colitis (UC) is a globally prevalent and refractory disease that imposes a substantial socioeconomic burden, with no universally effective ...

chinese-herbal-retention-enema-for-the-treatment-of-ulcerative-colitis

Research

JoVE Journal

Medicine

An enema is a type of traditional Chinese medicine (TCM) therapy used to treat severe acute pancreatitis (SAP). The therapy involves instilling a TCM liquid into the rectum and colon through the anus to keep the liquid in the intestine, absorbing through the intestinal mucosa. This study aims to standardize the enema procedure for SAP patients.

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

This protocol provides a mouse model of ulcerative coloproctitis-associated colorectal cancer induced by azomethane combined with dextran sulfate sodium. The model was used to evaluate the efficacy of traditional Chinese medicine compounds in the prevention and treatment of colorectal cancer.

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine

Sepsis refers to a systemic inflammatory response syndrome resulting from a microbial infection, and can be simulated by a surgical technique termed cecal ligation and puncture (CLP).  Here we describe a method to use CLP-induced animal model to screen medicinal herbs for therapeutic agents.

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

This protocol describes a procedure to track the evolution of mesial network measures in temporal lobe epilepsy (TLE) patients. It is based on the combination of intracranial recordings with a novel numerical technique for data analysis. Specifically, we present a protocol for network analyses of foramen ovale recordings.

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Current treatments of inflammatory bowel diseases (IBD) aim at alleviating disease symptoms but may cause severe side effects. Thus, alternative strategies are being investigated in animal colitis models. Here, we explain how the beneficial effects of diet supplements on clinical IBD signs are analyzed in such a colitis model.

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Here, we present the preparation of an er-xian decoction (EXD) in four steps—soaking, decoction, filtration, and concentration—and demonstrate the administration of a prepared EXD-containing serum to rats. These methods are applicable to the in vivo and in vitro study of herbal decoctions such as traditional Chinese medicines.

Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments

Miniature pigs (mini-pigs) are an ideal large animal model for research into cochlear implants. Cochlear implantation surgery in mini-pigs can be utilized to provide initial evidence of the safety and potential performance of novel electrode arrays and surgical approaches in a living system similar to human beings.

The Miniature Pig: A Large Animal Model for Cochlear Implant Research

The presented protocol describes an investigation strategy and systematic review to evaluate the clinical effectiveness and safety of Shugan Jieyu capsules for treating insomnia.

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

The objective of this study is to develop a novel 3D digital model of pulmonary nodules that serves as a communication bridge between physicians and patients and is also a cutting-edge tool for pre-diagnosis and prognostic evaluation.

A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules

The presented protocol describes a traditional Chinese medicine treatment procedure known for its safety and effectiveness in managing gestational vomiting.

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting

Learn Chinese herbal retention enema for ulcerative colitis treatment using clinical trial methods. This approach demonstrates improved symptom scores and quality of life compared to conventional oral mesalazine therapy.

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Explore More Videos