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JoVE Journal Neuroscience
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A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Article DOI: 10.3791/50761-v • 15:10 min • December 28th, 2013
December 28th, 2013 •
1, 1, 2, 3, 2, 2, 2,4, 1
1Research Center on Aging and Department of Physiology and Biophysics, Université de Sherbrooke, 2Sherbrooke Molecular Imaging Center, Étienne-Le Bel Clinical Research Center, Université de Sherbrooke, 3Department of Computer Science, Université de Sherbrooke, 4Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke

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Summary
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Small-animal positron emission tomography enables the assessment of the brain's two main energy substrates: glucose and ketones. In the present method, 11C-acetoacetate and 18F-fluorodeoxyglucose are injected sequentially in each animal, and their uptake is measured quantitatively in specific brain regions determined from the magnetic resonance images.

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Dual Tracer PET-MRI Protocol Quantitative Measure Regional Brain Energy Substrates Uptake Rat Glucose Ketones Acetoacetate Small-animal PET Protocol 11C-AcAc 18F-FDG Magnetic Resonance Imaging Coregistration Regional Cerebral Uptake Cortex Hippocampus Striatum Cerebellum Cerebral Metabolic Rate Kinetic Modeling Image-derived Input Function Method Radiotracers Brain Fuel Supply Normal Aging Neurodegenerative Pathologies
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