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Journal / Genetics / CRISPR-mediert reorganisering av Chromatin Loop…
JoVE Journal
Genetics

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JoVE Journal Genetics
CRISPR-mediert reorganisering av Chromatin Loop struktur
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CRISPR-mediert reorganisering av Chromatin Loop struktur

Article DOI: 10.3791/57457-v • 09:20 min • September 14th, 2018
September 14th, 2018 •
*1,2, *1, 1, 3, 4, 5, 1, 1, 1, 5, 3, 1,2,6
1Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, 2Program in Cancer Biology, Stanford University School of Medicine, 3Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, 4Department of Biology, Bridgewater State University, 5System Biosciences, 6Veterans Affairs Healthcare System
* These authors contributed equally

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Chromatin looping spiller en viktig rolle i genreguleringen; imidlertid har det vært ingen teknologiske fremskritt som tillate selektiv og reversibel endring av chromatin looper. Her beskriver vi et kraftig system for chromatin loop reorganisering bruker CRISPR-dCas9 (CLOuD9), viste til selektivt og reversibel modulerer genuttrykk på målrettet loci.

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Genetikk problemet 139 Chromatin looper chromatin folding gene uttrykk CRISPR dCas9 genreguleringen reversibel dimerization dynamisk chromosomal omorganisering.
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