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In JoVE (1)
Other Publications (16)
- Pacing and Clinical Electrophysiology : PACE
- Journal of Acquired Immune Deficiency Syndromes (1999)
- The Canadian Veterinary Journal. La Revue Vétérinaire Canadienne
- Journal of Acquired Immune Deficiency Syndromes (1999)
- The Canadian Veterinary Journal. La Revue Vétérinaire Canadienne
- Journal of Acquired Immune Deficiency Syndromes (1999)
- Biomedical and Environmental Sciences : BES
- Emerging Infectious Diseases
- New Solutions : a Journal of Environmental and Occupational Health Policy : NS
- The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
- Journal of Molecular Biology
- Indian Journal of Sexually Transmitted Diseases
- Indian Journal of Sexually Transmitted Diseases
- Journal of Chemical Theory and Computation
- Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)
- New Solutions : a Journal of Environmental and Occupational Health Policy : NS
Articles by Jagdish Patel in JoVE
JoVE Neuroscience
Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
1Center for Molecular and Behavioral Neuroscience, University of New Jersey, 2Center for Interdisciplinary Research in Biology, Collège de France, 3Janelia Farm Research Campus, Howards Hughes Medical Institute, 4Deptartment of Psychology, University of Wisconsin at Milwaukee
We describe methods for large-scale recording of multiple single units and local field potential in behaving rodents with silicon probes. Drive fabrication, probe attachment to the drive and probe implantation processes are illustrated in sufficient details for easy replication.
Other articles by Jagdish Patel on PubMed
Automatic Sensor Algorithms Expedite Pacemaker Follow-ups
Automatic algorithms can be used to optimize settings and reduce the duration of pacemaker (PM) clinical follow-up.
Safety and Antiretroviral Effectiveness of Concomitant Use of Rifampicin and Efavirenz for Antiretroviral-naive Patients in India Who Are Coinfected with Tuberculosis and HIV-1
To study the safety and antiretroviral effectiveness of concomitant use of rifampicin and efavirenz for antiretroviral-naïve patients in India who are coinfected with tuberculosis (TB) and HIV-1.
Effectiveness of Generic Fixed-dose Combinations of Highly Active Antiretroviral Therapy for Treatment of HIV Infection in India
To assess clinical and immunologic effectiveness and acute toxicity to nevirapine (NVP)-based fixed-dose combinations (FDCs) in antiretroviral-naive HIV-1-infected patients in India.
Renal Teratoma in a Llama
Teratomas are neoplasms of embryonal origin in domestic animals and are generally associated with reproductive organs. We report a case of teratoma involving the right kidney in a young llama that presented clinically with signs of mild colic and constipation.
Effectiveness of Low-dose Indinavir/ritonavir at 400/100 Mg Twice a Day with 2 Nucleoside Reverse Transcriptase Inhibitors in Nonnucleoside Reverse Transcriptase Inhibitor-experienced HIV-infected Patients in India: 1-year Follow-up
Isolation and Characterization of Nickel Uptake by Nickel Resistant Bacterial Isolate (NiRBI)
Bioremediation technology has gained importance because microbes could be the convenient source of bio-absorption/bioaccumulation of metals from effluent streams.
Swine Influenza (H3N2) Infection in a Child and Possible Community Transmission, Canada
An influenza A virus (H3N2) of probable swine origin, designated A/Canada/1158/2006, was isolated from a 7-month-old hospitalized child who lived on a communal farm in Canada. The child recovered uneventfully. A serosurvey that used a hemagglutination-inhibition assay for A/Canada/1158/2006 was conducted on 54 of the 90 members of the farm. Seropositivity was demonstrated in the index patient, 4 of 7 household members, and 4 of 46 nonhousehold members; none had a history of hospital admission for respiratory illness in the preceding year. Serologic evidence for this strain of swine influenza was also found in 1 of 10 pigs (12 weeks-6 months of age) on the farm. Human infection with swine influenza virus is underrecognized in Canada, and because viral strains could adapt or reassort into a form that results in efficient human-to-human transmission, routine surveillance of swine workers should be considered as part of pandemic influenza preparedness.
'Protective OSH Laws Available to Only a Few'
The American Public Health Association's occupational health and safety section honored Indian safety activist Jagdish Patel last year by giving him its International Award. Here is a brief look at his career followed by his talk at the APHA awards ceremony.
Distinct Representations and Theta Dynamics in Dorsal and Ventral Hippocampus
Although anatomical, lesion, and imaging studies of the hippocampus indicate qualitatively different information processing along its septo-temporal axis, physiological mechanisms supporting such distinction are missing. We found fundamental differences between the dorsal (dCA3) and the ventral-most parts (vCA3) of the hippocampus in both environmental representation and temporal dynamics. Discrete place fields of dCA3 neurons evenly covered all parts of the testing environments. In contrast, vCA3 neurons (1) rarely showed continuous two-dimensional place fields, (2) differentiated open and closed arms of a radial maze, and (3) discharged similar firing patterns with respect to the goals, both on multiple arms of a radial maze and during opposite journeys in a zigzag maze. In addition, theta power and the fraction of theta-rhythmic neurons were substantially reduced in the ventral compared with dorsal hippocampus. We hypothesize that the spatial representation in the septo-temporal axis of the hippocampus is progressively decreased. This change is paralleled with a reduction of theta rhythm and an increased representation of nonspatial information.
Molecular Modeling on Inhibitor Complexes and Active-site Dynamics of Cytochrome P450 C17, a Target for Prostate Cancer Therapy
A molecular model for the P450 enzyme cytochrome P450 C17 (CYP17) is presented based on sequence alignments of multiple template structures and homology modeling. This enzyme plays a central role in the biosynthesis of testosterone and is emerging as a major target in prostate cancer, with the recently developed inhibitor abiraterone currently in advanced clinical trials. The model is described in detail, together with its validation, by providing structural explanations to available site-directed mutagenesis data. The CYP17 molecule in this model is in the form of a triangular prism, with an edge of approximately 55 A and a thickness of approximately 37 A. It is predominantly helical, comprising 13 alpha helices interspersed by six 3(10) helices and 11 beta-sheets. Multinanosecond molecular dynamics simulations in explicit solvent have been carried out, and principal components analysis has been used to reveal the details of dynamics around the active site. Coarse-grained methods have also been used to verify low-frequency motions, which have been correlated with active-site gating. The work also describes the results of docking synthetic inhibitors, including the drug abiraterone and the natural substrate pregnenolone, in the CYP17 active site together with molecular dynamics simulations on the complexes.
Management of Cryptococcal Meningitis in HIV-infected Patients: Experience from Western India
Cryptococcal meningitis is one of the acquired immunodeficiency syndrome defining infections with high mortality. Amphotericin B is the preferred drug for induction therapy. Despite advances in human immunodeficiency virus (HIV) treatment, Antiretroviral Treatment (ART) roll-out programs and availability of amphotericin B, cryptococcal meningitis remains an important cause of mortality in the African and other developing countries.
Tenofovir-associated Renal Dysfunction in Clinical Practice: An Observational Cohort from Western India
Tenofovir (TDF) is preferred nucleoside reverse transcriptase inhibitors (NRTI) for the treatment of human immunodeficiency virus infection because of its potency and safety. Renal toxicity with TDF use is low and comparable with other NRTI in clinical trials, but there are many case studies and small case series of renal dysfunction with TDF.
Insights into Ligand-Protein Binding from Local Mechanical Response
Computational studies of ligand-protein binding are crucial for properly designing novel compounds of potential pharmacological interest. In this respect, researchers are increasingly interested in steered molecular dynamics for ligand-protein binding and unbinding studies. In particular, it has been suggested that analyzing the work profiles along the ligand-protein undocking paths could be fruitful. Here, we propose that small portions of work profiles, termed "local mechanical responses" of the system to a steering force, could serve as a universal measure for capturing relevant information about the system under investigation. Specifically, we first collected a high number of steering trajectories using two biological systems of increasing complexity (i.e., alanine dipeptide and (R)-roscovitine/CDK5 complex). Then, we devised a novel postprocessing tool to be applied to the local mechanical responses, to extract structural information related to the biological processes under investigation. Despite the out-of-equilibrium character of the trajectories, the analysis carried out on the work profiles provided pivotal information about the investigated biological processes. This could eventually be applied to drug design.
Comparison of the Effectiveness of Low-Dose Indinavir/Ritonavir (IDV/r)- Versus Atazanavir/Ritonavir (ATV/r)-Based Generic Antiretroviral Therapy in NNRTI-Experienced HIV-1-Infected Patients in India
Background: Currently, data on the effectiveness of second-line antiretroviral regimens using indinavir/ritonavir (IDV/r) and atazanavir/ritonavir (ATV/r) along with 2 nucleoside reverse transcriptase inhibitor (NRTI) in resource-poor settings is limited.
The Agate Industry and Silicosis in Khambhat, India
Agate stones have been shaped and polished into beads and other decorative items for thousands of years in Khambhat, India. Agate is a silicate quartz that produces a fine dust when shaped and polished. The people who shape and polish the stones in workshops in their homes are being sickened with silicosis, as are their families and neighbors. These home-based workshops are unregulated and the workers and their families have no access to occupational health services or workers' compensation when they become ill. Occupational health activists have tried to find an effective strategy to confront these working conditions and protect the health and livelihood of the agate workers. They have had limited success, and huge challenges remain.
