Scott J. Snipas NCI-designated Cancer Center Sanford Burnham Prebys Medical Discovery Institute Biography Publications Institution JoVE Articles Scott J. Snipas has not added a biography. If you are Scott J. Snipas and would like to personalize this page please email our Author Liaison for assistance. Publications Gain of Function of a Metalloproteinase Associated with Multiple Myeloma, Bicuspid Aortic Valve, and Von Hippel-Lindau Syndrome The Biochemical Journal. Jul, 2022 | Pubmed ID: 35789254 Resurrection of an Ancient Inflammatory Locus Reveals Switch to Caspase-1 Specificity on a Caspase-4 Scaffold The Journal of Biological Chemistry. 06, 2022 | Pubmed ID: 35427646 Evaluation of the Effects of Phosphorylation of Synthetic Peptide Substrates on Their Cleavage by Caspase-3 and -7 The Biochemical Journal. 06, 2021 | Pubmed ID: 34037204 Engineering Caspase 7 As an Affinity Reagent to Capture Proteolytic Products The FEBS Journal. 02, 2021 | Pubmed ID: 32619291 NETosis Occurs Independently of Neutrophil Serine Proteases The Journal of Biological Chemistry. 12, 2020 | Pubmed ID: 33454002 Activity Profiling and Crystal Structures of Inhibitor-bound SARS-CoV-2 Papain-like Protease: A Framework for Anti-COVID-19 Drug Design Science Advances. 10, 2020 | Pubmed ID: 33067239 Engineered Unnatural Ubiquitin for Optimal Detection of Deubiquitinating Enzymes Chemical Science. Jun, 2020 | Pubmed ID: 32953009 Multiplexed Probing of Proteolytic Enzymes Using Mass Cytometry-Compatible Activity-Based Probes Journal of the American Chemical Society. 09, 2020 | Pubmed ID: 32870676 Extended Subsite Profiling of the Pyroptosis Effector Protein Gasdermin D Reveals a Region Recognized by Inflammatory Caspase-11 The Journal of Biological Chemistry. 08, 2020 | Pubmed ID: 32554464 Noninvasive Optical Detection of Granzyme B from Natural Killer Cells with Enzyme-activated Fluorogenic Probes The Journal of Biological Chemistry. 07, 2020 | Pubmed ID: 32439802 Development of a Therapeutic Anti-HtrA1 Antibody and the Identification of DKK3 As a Pharmacodynamic Biomarker in Geographic Atrophy Proceedings of the National Academy of Sciences of the United States of America. 05, 2020 | Pubmed ID: 32345717 Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe Journal of Medicinal Chemistry. 03, 2020 | Pubmed ID: 32142286 Cytosolic Gram-negative Bacteria Prevent Apoptosis by Inhibition of Effector Caspases Through Lipopolysaccharide Nature Microbiology. 02, 2020 | Pubmed ID: 31873204 Exploring the Prime Site in Caspases As a Novel Chemical Strategy for Understanding the Mechanisms of Cell Death: a Proof of Concept Study on Necroptosis in Cancer Cells Cell Death and Differentiation. 02, 2020 | Pubmed ID: 31209360 Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation Cell Reports. 06, 2019 | Pubmed ID: 31216481 Potent and Selective Caspase-2 Inhibitor Prevents MDM-2 Cleavage in Reversine-treated Colon Cancer Cells Cell Death and Differentiation. 12, 2019 | Pubmed ID: 30976094 Caspase Selective Reagents for Diagnosing Apoptotic Mechanisms Cell Death and Differentiation. 02, 2019 | Pubmed ID: 29748600 Determination of Extended Substrate Specificity of the MALT1 As a Strategy for the Design of Potent Substrates and Activity-based Probes Scientific Reports. 10, 2018 | Pubmed ID: 30375474 Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples Journal of Medicinal Chemistry. 06, 2018 | Pubmed ID: 29806773 Extensive Peptide and Natural Protein Substrate Screens Reveal That Mouse Caspase-11 Has Much Narrower Substrate Specificity Than Caspase-1 The Journal of Biological Chemistry. 05, 2018 | Pubmed ID: 29414788 SHARPIN-mediated Regulation of Protein Arginine Methyltransferase 5 Controls Melanoma Growth The Journal of Clinical Investigation. 01, 2018 | Pubmed ID: 29227283 Highly Sensitive and Adaptable Fluorescence-quenched Pair Discloses the Substrate Specificity Profiles in Diverse Protease Families Scientific Reports. 02, 2017 | Pubmed ID: 28230157 Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes Cell Chemical Biology. 08, 2016 | Pubmed ID: 27478158 Caspase-11 Cleaves Gasdermin D for Non-canonical Inflammasome Signalling Nature. Oct, 2015 | Pubmed ID: 26375259 Quantification of Immunostained Caspase-9 in Retinal Tissue Crystal K. Colón Ortiz1, Anna M. Potenski2, Kendra V. Johnson1, Claire W. Chen1, Scott J. Snipas3, Ying Y. Jean1, Maria I. Avrutsky*1, Carol M. Troy*1,4,5 1Department of Pathology & Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, 2Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, 3NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 4Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, 5The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University JoVE 64237 Neuroscience
Quantification of Immunostained Caspase-9 in Retinal Tissue Crystal K. Colón Ortiz1, Anna M. Potenski2, Kendra V. Johnson1, Claire W. Chen1, Scott J. Snipas3, Ying Y. Jean1, Maria I. Avrutsky*1, Carol M. Troy*1,4,5 1Department of Pathology & Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, 2Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, 3NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 4Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, 5The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University JoVE 64237 Neuroscience